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Optimization of Extraction Process, Structural Characterization, and Antioxidant and Hypoglycemic Activity Evaluation of Polysaccharides From the Medicinal and Edible Plant: Cistanche deserticola Ma.
Phytochem Anal
January 2025
College of Pharmacy, Xinjiang Medical University, Urumqi, China.
Introduction: Cistanche deserticola Ma (CD), an edible and medicinal plant native to Xinjiang, Inner Mongolia, and Gansu in China, is rich in bioactive polysaccharides known for their health-promoting properties. The polysaccharides of C. deserticola (CDPs) have been shown to possess a range of beneficial activities, including immunomodulatory, anti-aging, antioxidant, and anti-osteoporosis effects.
View Article and Find Full Text PDFIntegrated Analysis of Bulk RNA Sequencing, eQTL, GWAS, and Single-Cell RNA Sequencing Reveals Key Genes in Hepatocellular Carcinoma.
J Cell Mol Med
January 2025
Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
Hepatocellular carcinoma (HCC) poses a continual therapeutic challenge owing to its elevated incidence and unfavourable prognosis, underscoring the critical need for the discovery of new molecular targets for detection and therapy. This work included the analysis of three publically accessible HCC datasets from TCGA and GEO. Instrumental variables (IVs) were derived via expression quantitative trait loci (eQTL) analysis, then followed by two-sample Mendelian randomisation (MR) analysis utilising publically available summary statistics.
View Article and Find Full Text PDFLipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial.
Metabolites
January 2025
Medical Department, Cantabria Labs Difa Cooper, 21042 Caronno Pertusella, Italy.
This study aimed to evaluate the efficacy of a novel "In & Out" strategy, combining topical and oral melatonin supplementation, in managing skin aging compared to topical treatment alone. A randomized, prospective study was conducted on 39 healthy females aged 55-69 years. Participants were divided into two groups: one received both the topical formula and oral melatonin supplementation (Group A), while the other received a topical melatonin-based formula (Group B).
View Article and Find Full Text PDFIntegration of Functional Materials in Photonic and Optoelectronic Technologies for Advanced Medical Diagnostics.
Biosensors (Basel)
January 2025
Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea.
Integrating functional materials with photonic and optoelectronic technologies has revolutionized medical diagnostics, enhancing imaging and sensing capabilities. This review provides a comprehensive overview of recent innovations in functional materials, such as quantum dots, perovskites, plasmonic nanomaterials, and organic semiconductors, which have been instrumental in the development of diagnostic devices characterized by high sensitivity, specificity, and resolution. Their unique optical properties enable real-time monitoring of biological processes, advancing early disease detection and personalized treatment.
View Article and Find Full Text PDFGuidelines for the Management of Complications of Diabetes in Saudi Arabia Using Delphi Technique for Consensus Among National Experts.
Clin Pract
December 2024
Saudi National Diabetes Center, Saudi Health Council, Riyadh 13315, Saudi Arabia.
(1) Background: Saudi Arabia has one of the leading cases of diabetes globally, with approximately 27.8% of adults suffering from the disease. Given the negative consequences of diabetes mellitus (DM), it is critical to develop guidelines for its management.
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