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Background: Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma (PTCL) and accounts for 2% of all non-Hodgkin lymphomas. Its typical characteristics include an aggressive course, progressive lymphadenopathy, hepatosplenomegaly, systemic symptoms, anemia, hypergammaglobulinemia, and generally poor prognosis.
Methods: We describe a rare case in which the left inguinal lymph node was completely excised and biopsied one year ago.
Single-cell transcriptomic and spatial analysis reveal the immunosuppressive microenvironment in relapsed/refractory angioimmunoblastic T-cell lymphoma.
Blood Cancer J
December 2024
Lymphoma Center, Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Angioimmunoblastic T-cell lymphoma (AITL) is a kind of aggressive T-cell lymphoma with significant enrichment of non-malignant tumor microenvironment (TME) cells. However, the complexity of TME in AITL progression is poorly understood. We performed single-cell RNA-Seq (scRNA-seq) and imaging mass cytometry (IMC) analysis to compare the cellular composition and spatial architecture between relapsed/refractory AITL (RR-AITL) and newly diagnosed AITL (ND-AITL).
View Article and Find Full Text PDFAngioimmunoblastic T-cell lymphoma harboring a t(8;14)(q24;q11.2)/TCR::MYC translocation that presented with intestinal infiltration.
Ann Hematol
December 2024
Department of Hematology, Tohoku University Hospital, Sendai, Japan.
Although rearrangement of the MYC oncogene (MYC-R) is frequently observed in aggressive B-cell lymphomas, it is extremely rare in T-cell malignancies. A 64-year-old man who had been under observation for several years because of asymptomatic pulmonary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALToma) was admitted to our hospital because of poor general condition and hypotension. Blood tests revealed thrombocytopenia and elevated serum lactate dehydrogenase levels, whereas computed tomography revealed systemic lymphadenopathy and splenomegaly.
View Article and Find Full Text PDFSynchronous Diagnosis of Angioimmunoblastic T-Cell Lymphoma and Lung Neuro-endocrine Cancer in a Patient.
J Coll Physicians Surg Pak
November 2024
Department of Haematology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
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View Article and Find Full Text PDFPulmonary Arterial Hypertension as an Unusual Presentation of Angioimmunoblastic T-Cell Lymphoma: A Case Report.
Case Rep Oncol
August 2024
Departments of Hematology-Oncology, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Article Synopsis
- Angioimmunoblastic T-cell lymphoma (AITL) is a rare type of non-Hodgkin lymphoma that can show various clinical symptoms, and this report discusses a specific case where it was accompanied by pulmonary arterial hypertension (PAH).
- An 84-year-old man with a history of gastric cancer showed symptoms like shortness of breath and was found to have lymphadenopathy, pleural effusion, and severe PAH, leading to the diagnosis of AITL through comprehensive testing.
- The patient responded well to a mini-CHOP chemotherapy treatment, significantly improving his PAH and symptoms, reaching complete remission, highlighting the need to consider AITL in patients presenting with symptoms like PAH.
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