Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Optical tweezers in biomedical research - progress and techniques.
J Med Life
November 2024
Biophysics and Cellular Biotechnology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Optical tweezers, which leverage the forces exerted by radiation pressure, have emerged as a pivotal technique for precisely manipulating and analyzing microscopic particles. Since Arthur Ashkin's ground-breaking work in the 1970s and the subsequent development of the single-beam optical trap in 1986, the capabilities of optical tweezers have expanded significantly, enabling the intricate manipulation of biological specimens at the micro- and nanoscale. This review elucidates the foundational principles of optical trapping and their extensive applications in the biomedical sciences.
View Article and Find Full Text PDFDiscovery of novel flavonoid derivatives containing benzothiazole as potential antifungal agents.
Pest Manag Sci
January 2025
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, China.
Background: Fungal diseases of plants have a serious impact on the quality and yield of crops, and some traditional pesticides can no longer cope with this problem. Therefore, it is of great significance to develop new pesticides with high efficiency and low toxicity.
Results: A series of flavonoid derivatives containing benzothiazole were designed and synthesized.
Restoration effect of chemically modified microRNA-143-3p on acute myocardial infarction in animal models.
Sci Rep
January 2025
Department of Circulatory and Respiratory Advanced Medicine, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194, Japan.
We investigated whether miR143#12, a synthesized chemically modified miR-143-3p derivative, exerts therapeutic effects on acute myocardial infarction (AMI). Sprague-Dawley rats and Japanese white rabbits underwent 30 min of coronary occlusion followed by 2 weeks of reperfusion. The rat AMI model was intravenously administered with control miRNA (9 μg/kg), 3 μg/kg or 9 μg/kg of miR143#12 1 h after reperfusion, while the rabbit AMI model was intravenously administered with control miRNA (9 μg/kg) or 9 μg/kg of miR143#12.
View Article and Find Full Text PDFMarcello Malpighi (1628-1694): His life, discoveries and struggles with the detractors of microscopic anatomy.
J Med Biogr
January 2025
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, USA.
Marcello Malpighi is widely recognized as the founder of microscopic anatomy. His seminal discoveries of the pulmonary alveoli, blood capillaries, and renal glomeruli revolutionized existing medical knowledge, earning him fame and international recognition. He discovered the respiratory system of insects and described, for the first time, their excretory apparatus.
View Article and Find Full Text PDFSelf-Supervised and Zero-Shot Learning in Multi-Modal Raman Light Sheet Microscopy.
Sensors (Basel)
December 2024
CeMOS Research and Transfer Center, Mannheim University of Applied Sciences, 68163 Mannheim, Germany.
Advancements in Raman light sheet microscopy have provided a powerful, non-invasive, marker-free method for imaging complex 3D biological structures, such as cell cultures and spheroids. By combining 3D tomograms made by Rayleigh scattering, Raman scattering, and fluorescence detection, this modality captures complementary spatial and molecular data, critical for biomedical research, histology, and drug discovery. Despite its capabilities, Raman light sheet microscopy faces inherent limitations, including low signal intensity, high noise levels, and restricted spatial resolution, which impede the visualization of fine subcellular structures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!