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Serum Neudesin Levels in Patients with Congenital Hypothyroidism.
J Clin Res Pediatr Endocrinol
January 2025
Cam and Sakura City Hospital Department of Pediatrics, Division of Pediatric Endocrinology, Istanbul, Turkey.
Objectives: Neudesin is a newly discovered protein mainly secreted from adipose tissue and the brain. It plays a role as a neurotrophic factor in the brain and a negative regulator of energy expenditure. Neurodevelopmental delay and cognitive dysfunction are common features in cases with congenital hypothyroidism (CH) without treatment.
View Article and Find Full Text PDFThe impact of oxidative balance on all-cause and cause-specific mortality in US adults and cancer survivors: evidence from NHANES 2001-2018.
BMC Cancer
January 2025
Department of family medicine & Division of General Internal Medicine, Department of internal medicine, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Chinese Academy of Medical Sciences, Beijing, China.
Background: Oxidative stress is a crucial pathophysiological mechanism in chronic diseases and mortality. While individual oxidative markers have been studied, the comprehensive impact of oxidative balance on mortality risks remains unclear, particularly among cancer survivors. We aimed to investigate the associations of Oxidative Balance Score (OBS) with mortality in both the general population and cancer survivors.
View Article and Find Full Text PDFDeciphering chondrocyte diversity in diabetic osteoarthritis through single-cell transcriptomics.
Comput Biol Chem
January 2025
Department of Otolaryngology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China. Electronic address:
The pathophysiological distinctions between osteoarthritis (OA) and diabetic osteoarthritis (DOA) are critical yet not well delineated. In this study, we employed single-cell RNA sequencing to clarify the unique cellular and molecular mechanisms underpinning the progression of both conditions. We identified a novel subpopulation of chondrocytes in DOA, termed 'Heat Shock' chondrocytes, marked by the expression of distinct molecular markers including HSPA1A, HSPA1B, HSPB1, and HSPA8.
View Article and Find Full Text PDFThe Pharmacokinetic Changes in Cystic Fibrosis Patients Population: Narrative Review.
Medicines (Basel)
December 2024
Pharmacy School, West Coast University, Los Angeles, CA 90004, USA.
Cystic fibrosis (CF) is a rare genetic disorder commonly affecting multiple organs such as the lungs, pancreas, liver, kidney, and intestine. Our search focuses on the pathophysiological changes that affect the drugs' absorption, distribution, metabolism, and excretion (ADME). This review aims to identify the ADME data that compares the pharmacokinetics (PK) of different drugs in CF and healthy subjects.
View Article and Find Full Text PDFEffects of Age and Sex on Systemic Inflammation and Cardiometabolic Function in Individuals With Type 2 Diabetes.
J Am Heart Assoc
January 2025
Rongxiang Xu Center for Regenerative Therapeutics, Microcirculation Lab, Beth Israel Deaconess Medical Center Harvard Medical School Boston MA.
Background: Systemic inflammation, aging, and type 2 diabetes (T2D) lead to varying degrees of cardiovascular dysfunction and impaired aerobic exercise capacity. This study evaluates the impact of inflammation and sex differences on coronary and peripheral vascular function and exercise capacity in older individuals with and without T2D.
Methods: Older individuals (aged≥65 years) underwent biochemical and tissue inflammatory phenotyping, cardiopulmonary exercise testing, cardiovascular magnetic resonance imaging, and vascular reactivity testing.
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