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Capnodynamic determination of end-expiratory lung volume in a porcine model of hypoxic pulmonary vasoconstriction.
J Clin Monit Comput
December 2024
Pediatric perioperative medicine and Intensive Care, Karolinska University Hospital, Eugeniavägen 23, Stockholm, 171 64, Sweden.
Purpose: The capnodynamic method, End Expiratory Lung Volume CO (EELV-CO), utilizes exhaled carbon dioxide analysis to estimate End-Expiratory Lung Volume (EELV) and has been validated in both normal lungs and lung injury models. Its performance under systemic hypoxia and variations in CO elimination is not examined. This study aims to validate EELV-CO against inert gas wash in/wash out (EELV- SF6, sulfur hexafluoride) in a porcine model of stable hemodynamic conditions followed by hypoxic pulmonary vasoconstriction and inhaled nitric oxide (iNO).
View Article and Find Full Text PDFClinical usefulness of an ultra-high-sensitivity hepatitis B surface antigen assay to determine the cessation of treatment for HBV reactivation.
Ann Hepatol
December 2024
Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Introduction And Objectives: We aimed to compare the usefulness of the ultra-high-sensitivity hepatitis B surface antigen (iTACT-HBsAg), high-sensitivity hepatitis B core-related antigen (iTACT-HBcrAg), and anti-HBs assays in determination of cessation of nucleot(s)ide analogue (NA) treatment to prevent against hepatitis B virus (HBV) reactivation.
Patients And Methods: Twenty-two patients who developed HBV reactivation under immunosuppressive therapy or chemotherapy and had been administered NA and subsequently discontinued were enrolled. The stored serum samples taken at NA cessation were applied to iTACT-HBsAg (lower limit of detection; 0.
Predicting the risk of malaria importation into Jiangsu Province, China: a modeling study.
Global Health
November 2024
Institute of Public Health, Medical School of Yangzhou University, Yangzhou University, Yangzhou, Hanjiang District, 225007, China.
Background: The World Health Organization certified China malaria-free in 2021. Consequently, preventing the risk of malaria re-introduction caused by imported malaria has now become a major challenge. This study aims to characterize the dynamics and predict the risk of malaria importation in Jiangsu Province, where the number of imported malaria cases ranks among the highest in China.
View Article and Find Full Text PDFComprehensive phylogenomic analysis of Zika virus: Insights into its origin, past evolutionary dynamics, and global spread.
Virus Res
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Center Agriculture Food Environment (C3A), University of Trento, 38010, San Michele all'Adige, TN, Italy.
Background: Zika virus (ZIKV), a Flaviviridae family member, has been linked to severe neurological disorders. Despite detailed studies on recent outbreaks, the early evolutionary history of ZIKV remains partially unclear. This study elucidates ZIKV origin and evolutionary dynamics, focusing on recombination events, early lineage diversification, and virus spread across continents.
View Article and Find Full Text PDFSuccessful captive breeding of vultures due to the double clutching method.
Biodivers Data J
August 2024
Green Balkans - Stara Zagora NGO, Stara Zagora, Bulgaria Green Balkans - Stara Zagora NGO Stara Zagora Bulgaria.
After a massive decline, the Griffon Vulture () population in Bulgaria has now stabilised as a result of the hard work of conservation programmes, although it is still listed as an Endangered species (EN) in the country's Red Data Book. Due to a series of unfortunate events, another species - the Cinereous Vulture () became extinct in Bulgaria and recovered only recently due to systematic re-introduction efforts. Along with the poor living conditions, a predisposing factor for the decreasing population of the vultures is the fact they hatch only a single egg; two may be laid on exceptions.
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