A qualitative and clinical evaluation of a radioimmunoassay for a carcinoembryonic antigen (CEA) fraction in serum is presented. The technique shows cross-reactions with normal organs' extracts lower than 0.05% and a 0.9977 correlation coefficient. The coefficients of variation indicate satisfactory precision. In the clinical study it was found that sensitivity for lung cancer was higher than for colorectal cancer. Specificity for cancer was 98.3%. These results suggest that the CEA fraction employed shows more lung cancer determinants than for digestive cancer.
Download full-text PDF |
Source |
---|
Anal Methods
May 2024
Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis 157 71, Greece.
Carcinoembryonic antigen (CEA) is a glycoprotein widely used as a tumor marker. In this work, a colorimetric lateral flow immunosensor is developed for rapid and low-cost quantification of CEA in human blood serum. The immunosensor consists of a glass fiber sample/conjugation pad, a nitrocellulose detection pad and a cellulose absorption pad.
View Article and Find Full Text PDFNeoplasma
May 2022
Division of In Vitro Diagnostics, Shenzhen Mindray Bio-Medical Electronics Corporation, Shenzhen, Guangdong, China.
The value of serum tumor biomarkers used for lung cancer diagnosis is still controversial in clinical practice. This study aimed to further dissect and evaluate the clinical value of serum progastrin-releasing peptide (ProGRP), neuron-specific enolase (NSE), squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), cytokeratin-19 fragment (CYFRA21-1) together with a potential new biomarker, the human epididymis protein 4 (HE4) for lung cancer diagnosis, in a large cohort of a Chinese population. Ostensibly healthy individuals, as well as those with benign non-cancerous diseases, benign tumors, lung cancers, and other types of malignancies, were enrolled in the study.
View Article and Find Full Text PDFCancer
August 2021
Pathology Consultants, Westlake Village, California.
During the period from 1962 to 1977, several antigens, notably carcinoembryonic antigen and prostate-specific antigen, were discovered and entered clinical use. Ultrasonography, positron emission tomography scanning, and magnetic resonance imaging were introduced, and adjuvant radiation and chemotherapy after limited surgery became routine procedures. Radioimmunoassay and immunohistochemistry techniques were standardized.
View Article and Find Full Text PDFArab J Gastroenterol
June 2019
Clinical Pathology, Health Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
Background And Study Aims: Cytokines play a pivotal role in the induction of host immune responses against tumour growth and are involved in the development and progression of colorectal cancer in humans. The role of IL-23 in colorectal cancer is still unclear. Thus, we aimed to determine IL-23 levels in the development and progression of colorectal (CRC) cancer.
View Article and Find Full Text PDFJ Med Biochem
July 2018
Radiation Health Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. The tumor microenvironment is very important for determining cancer cell growth and spreading. Chemerin, a newly identified adipokine secreted by adipose tissue, is known to be associated with obesity, metabolic syndrome, and insulin resistance.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!