The influence of PUVA treatment on junction A-cell nevi in psoriatic patients has been analysed. After long-term PUVA therapy the nevocytes display an obvious increase in melanosome synthesis. The melanosomes are clearly polymorphous, without any predominant configuration. The structural organization of the melanosomes is profoundly aberrant. Formation of autophagosomes is conspicuous. The cytoplasmic filaments are displaced peripherally. No convincing signs of malignancy are observed electron microscopically. Light microscopical findings of a bridging proliferation of nevocytes between junction nests is a precautionary observation, however.
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