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An Italian nationwide survey on the evolution of autoantibody diagnostics in autoimmune rheumatic diseases.
Clin Exp Rheumatol
November 2023
Laboratorio di Patologia Clinica, Ospedale San Antonio, Azienda Sanitaria Universitaria Integrata di Udine, Italy.
Article Synopsis
- The Italian Society of Clinical Pathology and Laboratory Medicine conducted a nationwide survey to evaluate the adoption of new autoimmune diagnostic technologies and practices among autoimmunology laboratories in Italy.
- A questionnaire featuring 59 questions was distributed to 152 laboratories, assessing factors like test volume, technology used, automation level, testing methods, and interaction with clinicians.
- Results showed a high response rate (79.6%) with most labs using various advanced testing technologies and 65% providing interpretative comments in reports, suggesting a trend towards enhanced testing capabilities and closer collaboration with healthcare providers.
Risk markers of reproductive loss in women with hyperandrogenism.
Wiad Lek
June 2019
Ukrainian Medical Stomatological Academy, Poltava, Ukraine.
Objective: Introduction: The frequency of the pathological course of pregnancy with hyperandrogenism ranges from 21 to 48%. With the predominance of androgens against the background of lowering the normal products of steroidogenesis, a pro-inflammatory immune imbalance is formed, which causes a premature termination of the development of pregnancy. Many studies indicate that hyperandrogenism is a factor in the development of obstetric pathology, including placental dysfunction.
View Article and Find Full Text PDFBackground: Direct antiglobulin test (DAT)-negative warm autoimmune hemolytic anemia (AIHA) is mainly caused by three mechanisms: red blood cell (RBC)-bound immunoglobulin (Ig)G below the detection limit of routine DAT; RBC-bound IgA or IgM; or low-affinity autoantibodies. Although most cases of DAT-negative AIHA are thought to be caused by RBC-bound IgG, and combinatory serological analyses are recommended, the relative ratios of each mechanism have not been clarified.
Methods: Two groups of patients with undiagnosed hemolytic anemia and negative conventional tube method-DAT (TM-DAT) were investigated using anti-IgA and anti-IgM sera, or column agglutination method-DAT (CM-DAT), respectively, in addition to radioimmunological quantitation of RBC-bound IgG.
Background: Vitamin D deficiency and insufficiency have been reported in fibromyalgia. However, to the best of our knowledge, only one study has evaluated the role of 25-hydroxyvitamin D [25(OH)D] supplementation on fibromyalgia symptoms.
Objectives: To analyze the effects of 3 months of 25(OH)D supplementation on symptoms of fibromyalgia.
Hydatidosis: Preparation and evaluation of radiolabeled antigens and antibodies.
Exp Parasitol
April 2018
Laboratoire de physiologie cellulaire et animale, Ecole Normale Supérieure, B.P., 92 Kouba, Algeria.
The present preliminary study intends to evaluate the in vitro use of hydatid antigen and their antibodies once labeled with iodine 125(I) and characterized from viewpoint of radiochemical purity and immunoreactivity. Radiolabelled molecules gave satisfactory purity of 94% and 96%-98%, for hydatid antigen and IgG respectively. As regards, the specific activity of these latter, varied between 4.
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