Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Impaired hemostatic and immune functions of platelets after acute thrombocytopenia.
J Thromb Haemost
December 2024
Institute of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. Electronic address:
Background: Platelets are pivotal in maintaining vascular integrity, hemostasis, and immune modulation, with newly generated, immature platelets being the most responsive in fulfilling these tasks. Therefore, the immature platelet fraction provides insights into thrombopoiesis dynamics and clinical prognostication. However, it is currently unclear how immature platelet functions change in settings of acute thrombocytopenia.
View Article and Find Full Text PDFIs a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy-Associated Systemic Capillary Leak Syndrome).
Arterioscler Thromb Vasc Biol
December 2024
Lung and Vascular Inflammation Section, Laboratory of Allergic Diseases (E.C.C., A.J.A., A.D., K.M.D.), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD.
Article Synopsis
- Vascular leakage is a serious complication of severe infections like septicemia and malaria, leading to shock and multi-organ dysfunction, with a specific syndrome (MG-CLS) causing recurrent severe episodes triggered by minor infections.
- Researchers identified loss-of-function mutations in the PARP15 gene present in MG-CLS patients, linked to reduced enzyme function and increased vascular leakage.
- The PARP15 enzyme plays a crucial role in protecting blood vessel integrity during inflammation by inhibiting certain pathways, indicating a genetic factor influencing susceptibility to MG-CLS-related vascular issues.
Cardiac Fibroblasts regulate myocardium and coronary vasculature development via the collagen signaling pathway.
bioRxiv
September 2024
Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA.
The fibroblast (FB), cardiomyocyte (CM), and vascular endothelial cell (Vas_EC) are the three major cell types in the heart, yet their relationships during development are largely unexplored. To address this gap, we employed RNA staining of the FB marker gene together with the CM marker gene and the Vas_EC marker gene at different stages. This approach enabled us to discern the anatomical pattern of cardiac FBs and identify approximately one EC and four CMs directly interacting with each FB.
View Article and Find Full Text PDFFrom the Gorgon's blood to Behring's Blutserumtherapie: A long path towards serum therapy.
Immunol Rev
November 2024
Université de Tours and INSERM, UMR 1100, Tours, France.
At the end of the 19th century medicine was turned upside down by the development of serum therapy, a great therapeutic revolution as was vaccination a few years earlier. Many serums were developed, the most famous being the German doctor Emil von Behring's diphtheria serum, which saved countless children's lives from this dreadful disease. The discovery of the serum therapy principle, allowed by the progressive understanding of humoral immunity, occurred both in Germany and France, almost at the same time.
View Article and Find Full Text PDFIdentification of potential inhibitors against Corynebacterium diphtheriae MtrA response regulator protein; an in-silico drug discovery approach.
J Mol Graph Model
December 2024
National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Article Synopsis
- Corynebacterium diphtheriae is a multi-drug resistant bacteria that causes diphtheria, a serious respiratory illness that can lead to severe nervous system issues if untreated.
- The study focused on the MtrA response regulator of this bacteria, as it is crucial for bacterial pathogenesis and cell division, and aimed to develop drugs inhibiting this protein using computational methods.
- Three promising small molecule inhibitors were identified through molecular docking and dynamics simulations, with the need for further in vivo and in vitro studies to confirm their effectiveness as therapeutic agents for C. diphtheriae infections.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!