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Effects of Earthworm () extract on atopic dermatitis: An in vitro and in vivo study.
Heliyon
January 2025
KM Science Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 34054, South Korea.
Earthworm () is used as a traditional medicine for the management of allergic airway inflammation. Atopic dermatitis (AD) is a persistent, recurrent disorder marked by allergic inflammation and skin barrier dysfunction. However, the pharmaceutical effects of earthworms on AD have not been defined.
View Article and Find Full Text PDFEvaluation methods using tear volume in a conjunctivitis mice model.
J Pharmacol Toxicol Methods
July 2024
Department of Inflammatory Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. Electronic address:
Allergic conjunctival disease is an immune-mediated inflammatory disease of the conjunctiva. To develop clinically useful drugs, it is necessary to develop quantitative evaluation methods that reflect the clinical symptoms in experimental animal models. Allergic conjunctivitis model mice were systemically sensitised with ovalbumin (OVA) administered intraperitoneally and locally sensitised with OVA eye drops between day 14-28.
View Article and Find Full Text PDFKamebakaurin Suppresses Antigen-Induced Mast Cell Activation by Inhibition of FcεRI Signaling Pathway.
Int Arch Allergy Immunol
September 2024
Department of Pharmacology, College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan.
Article Synopsis
- Kamebakaurin, derived from Rabdosia japonica and Rabdosia excisa, is explored for its potential anti-allergic effects, specifically targeting cellular mechanisms in mast cells.
- Experiments demonstrated that kamebakaurin inhibits key processes like degranulation, histamine release, and production of inflammatory mediators, showing stronger effects at higher concentrations (30 μM).
- The compound works by binding to the ATP-binding site of the Syk protein, reducing its auto-phosphorylation, which is crucial for allergy-related reactions, and it also mitigates antigen-triggered vascular hyperpermeability.
Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells.
Eur J Immunol
December 2023
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
In the present study, we found that methiothepin (a nonselective 5-hydroxytryptamine [5-HT] receptor antagonist) inhibited antigen-induced degranulation in rat basophilic leukemia cells and mouse bone marrow-derived mast cells. Although antigen stimulation induces release of histamine and serotonin (5-HT) by exocytosis and mast cells express several types of 5-HT receptor, the detailed role of these receptors remains unclear. Here, pretreatment of cells with methiothepin attenuated increased intracellular Ca concentration, phosphorylated critical upstream signaling components (Src family tyrosine kinases, Syk, and PLCγ1), and suppressed TNF-α secretion via inhibition of Akt (a Ser/Thr kinase activated by PI3K)and ERK phosphorylation.
View Article and Find Full Text PDFMechanisms for hypothermia during anaphylactic hypotension in awake rats.
Am J Physiol Regul Integr Comp Physiol
November 2023
Department of Physiology II, Kanazawa Medical University, Ishikawa, Japan.
Article Synopsis
- The study investigates how hypothermia occurs during systemic anaphylaxis in rats, focusing on factors like movement, heat loss, and brown adipose tissue (BAT) activity.
- Results show that during anaphylaxis, blood pressure drops significantly and body temperature decreases, mainly due to reduced locomotor activity rather than increased heat dissipation or reduced BAT activity.
- Chemical mediators such as platelet-activating factor (PAF) and histamine primarily contribute to low blood pressure but only partially affect the accompanying hypothermia during anaphylactic reactions.
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