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The heterologous binding of human IgG to mouse peritoneal mast cells was studied in vitro. The specific percentage of mast cell degranulation after treatment with sera heated for 2 hours at 57 degrees C was determined. These sera were obtained from normal or allergic patients, skin test positive to grass mix or dust, and then challenged separately with each allergen. The results show a high performance of degranulation by anti-human IgG and a direct correlation between skin test positivity and high degranulation values.
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