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Physical exercise halts further functional decline in an animal model for Charcot-Marie-Tooth disease 1X at an advanced disease stage.
J Peripher Nerv Syst
December 2024
Department of Neurology, Developmental Neurobiology, University Hospital Würzburg, Würzburg, Germany.
Article Synopsis
- Charcot-Marie-Tooth (CMT) type 1 neuropathies are common inherited disorders affecting the peripheral nervous system, with over 100 associated genes identified but lacking effective treatments.
- A study using Cx32def mice, a model for CMT1X, showed that late-onset voluntary wheel running (VWR) significantly improved functional outcomes, neuromuscular innervation, and axonal health despite advanced disease stages, unlike early-onset exercise which influenced nerve inflammation.
- The findings suggest that physical exercise could be a promising therapeutic option for CMT1 patients even after the onset of disease symptoms, emphasizing its potential benefits in managing the condition.
Angelica sinensis polysaccharides ameliorate 5-FU-induced stress anemia via promoting extramedullary erythroblastic island central macrophage-mediated erythroid differentiation.
Int Immunopharmacol
December 2024
Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, China. Electronic address:
Article Synopsis
- Chronic anemia, especially from chemotherapy, is a serious problem that can be hard to treat and can cause side effects from traditional treatment options.
- Researchers studied how a substance from a Chinese herb called Angelica sinensis (ASP) helps mice recover from anemia caused by the chemotherapy drug 5-fluorouracil (5-FU).
- The study found that ASP helped mice produce more red blood cells and other blood components by improving their bone marrow and spleen function, showing that it could be a helpful treatment for anemia caused by cancer treatments.
Morin suppresses mTORc1/IRE-1α/JNK and IP3R-VDAC-1 pathways: Crucial mechanisms in apoptosis and mitophagy inhibition in experimental Huntington's disease, supported by in silico molecular docking simulations.
Life Sci
February 2024
Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt.
Aims: Endoplasmic reticulum stress (ERS) with aberrant mitochondrial-ER contact (MERC), mitophagy, and apoptosis are interconnected determinants in neurodegenerative diseases. Previously, we proved the potential of Morin hydrate (MH), a potent antioxidant flavonoid, to mitigate Huntington's disease (HD)-3-nitropropionic acid (3-NP) model by modulating glutamate/calpain/Kidins220/BDNF trajectory. Extending our work, we aimed to evaluate its impact on combating the ERS/MERC, mitophagy, and apoptosis.
View Article and Find Full Text PDFLimosilactobacillus reuteri 29A Cell-Free Supernatant Antibiofilm and Antagonistic Effects in Murine Model of Vulvovaginal Candidiasis.
Probiotics Antimicrob Proteins
December 2023
Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 43400 UPM, Malaysia.
Vaginal dysbiosis advocates burgeoning of devious human vaginal pathobionts like Candida species that possess multiple virulence properties and metabolic flexibility to cause infections. Inevitably, antifungal resistance may emerge due to their innate nature (e.g.
View Article and Find Full Text PDFAssessment of modulatory activity of Uncaria tomentosa extract against fipronil immunotoxicity in male rats.
Ecotoxicol Environ Saf
August 2021
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University, El-Arish 45513, Egypt.
This study has investigated the effect of using the Uncaria tomentosa (UT) extract against immunotoxicity that induced by fipronil (FP) in male Wistar rats. Twenty-eight, male Wistar rats were assigned randomly into four groups (7 rats each). Control group received distilled water.
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