The results of endolymphatic chemotherapy and lymphography in 57 cases of different malignant neoplasms in the lymphatic system are presented. Procedures for making alcohol-oil solution of benzo-TEP, ether-oil solution of tio-TEP and alcohol-oil emulsion of cyclophosphamide are discussed and the clinical evaluation of the results of their application is given. The therapeutic effect of endolymphatic infusions of the mixtures of alkylating agents and iodolipol was assessed on the basis of clinical, histological and radiological examination of malignant lesions of lymph nodes. It is shown that the efficacy of endolymphatic chemotherapy is determined by the susceptibility of neoplasms to antitumor drugs and the availability of the latter at lymph node metastases.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Efficacy of endolymphatic duct blockage in treating Ménières disease.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2024
Department of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.
Article Synopsis
- Ménière's disease (MD) is an inner ear disorder causing vertigo, hearing loss, tinnitus, and ear fullness, primarily treated through endolymphatic sac (ES)-related surgery for patients not responding to medications.
- This study analyzed 33 patients who underwent endolymphatic duct blockage (EDB) surgery, comparing outcomes based on the morphology of their ES (normal vs. atrophic types).
- Results showed that patients with normal-type ES had significantly better control of vertigo and improved cochlear function, along with a notable reversal of endolymphatic hydrops, indicating different disease mechanisms between the two types.
Endolymphatic Sac Tumors Associated With von Hippel-Lindau: A Case Report Highlighting Opportunity for Novel Orphan Drug Therapy.
Otol Neurotol
October 2024
Department of Otolaryngology-Head and Neck Surgery, Jefferson Health, Philadelphia, Pennsylvania.
Objective: To discuss the potential benefit of belzutifan therapy in a patient with von Hippel-Lindau (VHL) disease-associated endolymphatic sac tumor (ELST).
Patients: Case report.
Interventions: Clinical details of a patient with residual ELST after hearing preservation surgery who initiated belzutifan therapy postoperatively for concurrent renal cell carcinoma, as well as literature review of belzutifan and ELST.
Intratympanic Gentamicin Injection for Endolymphatic Hydrops After Cochlear Implantation.
J Int Adv Otol
March 2024
Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Endolymphatic hydrops has been documented as a possible complication of cochlear implantation; however, few studies have addressed its treatment. We describe the first case ever reported of delayed endolymphatic hydrops after a cochlear implant successfully treated with intratympanic gentamicin injection. A detailed discussion of this case with a focus on its management and outcomes will be provided in comparison with literature data.
View Article and Find Full Text PDFAtrial Natriuretic Peptide Alleviates Motion Sickness Potentially through Regulating Endolymph Volume in the Inner Ear Increased by Arginine Vasopressin.
Neuroendocrinology
August 2024
Department of Nautical and Diving Medicine, Institute of Nautical Medicine, Institute of Special Environmental Medicine, Medical School, and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Introduction: Dimenhydrinate and scopolamine are frequently used drugs, but they cause drowsiness and performance decrement. Therefore, it is crucial to find peripheral targets and develop new drugs without central side effects. This study aimed to investigate the anti-motion sickness action and inner ear-related mechanisms of atrial natriuretic peptide (ANP).
View Article and Find Full Text PDFEndolymphatic duct blockage surgery vs. intratympanic steroids for treatment of refractory Ménière's disease.
Eur Arch Otorhinolaryngol
October 2024
University of Montreal Hospital Centre Research Centre (CRCHUM), Montreal, QC, Canada.
Purpose: To compare the effectiveness of the Endolymphatic duct blockage (EDB) and intratympanic methylprednisolone(ITMP) injection to control refractory Ménière's disease(MD) symptoms and evaluate their impact on hearing level.
Study Design: Retrospective study in a tertiary care center.
Methods: 36 received ITMP injection and 52 EDB.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!