AI Article Synopsis
- Intracellular proteases are crucial for both general and specific immune responses, interacting with phagocytic factors that help kill microorganisms.
- Results show that proteases released by dying leukocytes can alter antibody function, specifically lowering their ability to fix complement.
- Different types of macrophages (alveolar vs. peritoneal) have varying effects on antibody formation, with alveolar macrophages reducing immunogenicity and peritoneal macrophages enhancing it in immunized rabbits.
Article Abstract
Intracellular proteases play an important role both in nonspecific and specific immune reactions. Results concerning the interaction of these enzymes with phagocytic factors responsible for killing microorganisms are presented. In inflammatory foci, proteases released from destroyed leukocytes have been found to modify the function of antibodies present. They particularly reduce their complement fixation activity. Macrophages with differing proteolytic activity demonstrated diverse effects on the formation of antibodies tested by Jerne's plaque technique in young rabbits immunized with sheep erythrocytes. Whereas alveolar macrophages diminished antigen immunogenicity, peritoneal macrophages enhanced it.
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