Download full-text PDF

Source

Publication Analysis

Top Keywords

burn-induced immunological
4
immunological modifications
4
modifications preliminary
4
preliminary levamisole
4
burn-induced
1
modifications
1
preliminary
1
levamisole
1

Similar Publications

Article Synopsis
  • The study highlights the importance of understanding the genetic, acquired, and immunological causes of limbal stem cell deficiency (LSCD) and its ocular manifestations, which can range from mild symptoms like dry eye to severe issues like vision loss.
  • A comprehensive review was conducted using 99 articles published from November 1986 to October 2022, focusing on the various causes and treatments for LSCD found in reputable databases.
  • The findings stress the necessity of accurately identifying the source of LSCD damage to tailor appropriate treatments, which may include more than just standard methods and could involve advanced options like stem cell transplants.
View Article and Find Full Text PDF

Severity of thermal burn injury is associated with systemic neutrophil activation.

Sci Rep

January 2022

Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Burn injuries elicit a unique and dynamic stress response which can lead to burn injury progression. Though neutrophils represent crucial players in the burn-induced immunological events, the dynamic secretion pattern and systemic levels of neutrophil-derived factors have not been investigated in detail so far. Serum levels of neutrophil elastase (NE), myeloperoxidase (MPO), citrullinated histone H3 (CitH3), and complement factor C3a were quantified in burn victims over 4 weeks post injury.

View Article and Find Full Text PDF

microRNAs regulate numerous biological processes, making them potential therapeutic agents. Problems with delivery and stability of these molecules have limited their usefulness as treatments. We demonstrate that synthetic high-density lipoprotein nanoparticles (HDL NPs) topically applied to the intact ocular surface are taken up by epithelial and stromal cells.

View Article and Find Full Text PDF

Infection is a common and severe complication of burn injury: Sepsis accounts for 47% of postburn mortality. Burn-induced T cell suppression likely contributes to the increased infection susceptibility in burn patients. However, little is known about the kinetics of T cell dysfunction after burn and its underlying mechanisms.

View Article and Find Full Text PDF

Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies mainly target the hemidesmosomal component BP180 (also known as type XVII collagen) in basal keratinocytes. Various triggering factors are known to induce BP onset, including radiotherapy, burns, ultraviolet exposure, surgery, and the use of dipeptidyl peptidase-IV inhibitors (DPP4i), which are widely used antihyperglycemic drugs. Here, we present a case of BP triggered by a thermal burn under medication with DPP4i.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!