Afferent sources from meso-diencephalon to n. raphe magnus (RM) were examined by the HRP method. Following HRP injection into RM, HRP-labeled cell clusters occurred in: (1) n.linealis rostralis; (2) ventrocaudal part of n.parafascicularis; (3) zona incerta; and (4) midbrain reticular formation. As a rule, the axons from (1) and (4) mainly terminate within RM, while those from (2) and (3) seem to project to the inferior olive (IO) as well as RM. The functional significance of these nuclei is briefly discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0006-8993(81)90710-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Postcolitis Alterations in Dose-Dependent Effects of 5-HT1A Agonist Buspirone on Nociceptive Activity of the Raphe Magnus and Dorsal Raphe Neurons in Rats.
Eur J Neurosci
January 2025
Laboratory of Cortico-Visceral Physiology, Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg, Russia.
The serotonergic raphe magnus (RMg) and dorsal raphe (DR) nuclei are crucial pain-regulating structures, which nociceptive activity is shown to be altered in gut pathology, but the underlying neuroplastic changes remain unclear. Considering the importance of 5-HT1A receptors in modulating both pain and raphe neuronal activity, in this study, we aimed to determine whether 5-HT1A-dependent visceral and somatic nociceptive processing within the RMg and DR is modified in postcolitis conditions. In anaesthetised male Wistar rats, healthy control and recovered from TNBS-induced colitis, the microelectrode recordings of RMg and DR neuron responses to noxious colorectal distension (CRD) or tail squeezing (TS) were performed prior and after intravenous administration of 5-HT1A agonist, buspirone.
View Article and Find Full Text PDFBrainstem serotonin amplifies nociceptive transmission in a mouse model of Parkinson's disease.
NPJ Parkinsons Dis
January 2025
Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France.
Parkinson's disease arises from the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as akinesia, rigidity, and tremor at rest. The non-motor component of Parkinson's disease includes increased neuropathic pain, the prevalence of which is 4 to 5 times higher than the general rate. By studying a mouse model of Parkinson's disease induced by 6-hydroxydopamine, we assessed the impact of dopamine depletion on pain modulation.
View Article and Find Full Text PDFThe landscape of therapeutic deep brain stimulation (DBS) for locomotor function recovery is rapidly evolving. This review provides an overview of electrical neuromodulation effects on spinal cord injury (SCI), focusing on DBS for motor functional recovery in human and animal models. We highlight research providing insight into underlying cellular and molecular mechanisms.
View Article and Find Full Text PDFMultiple Posterior Insula Projections to the Brainstem Descending Pain Modulatory System.
Int J Mol Sci
August 2024
Department of Biological Applications and Technology, University of Ioannina, 45110 Ioannina, Greece.
The insular cortex is an important hub for sensory and emotional integration. It is one of the areas consistently found activated during pain. While the insular's connections to the limbic system might play a role in the aversive and emotional component of pain, its connections to the descending pain system might be involved in pain intensity coding.
View Article and Find Full Text PDFRepeated seizure-induced brainstem neuroinflammation contributes to post-ictal ventilatory control dysfunction.
Front Physiol
August 2024
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, United States.
Patients with epilepsy face heightened risk of post-ictal cardiorespiratory suppression and sudden unexpected death in epilepsy (SUDEP). Studies have shown that neuroinflammation, mediated by the activation of microglia and astrocytes, may be a cause or consequence of seizure disorders. Kcnj16 (Kir5.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!