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Lupus progression deteriorates oogenesis quality in MRL/lpr mice.
Immunol Res
August 2024
Department of Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 26, 1113, Sofia, Bulgaria.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of the immune response against self antigens. Numerous reproductive complications, including reduced birth rate and complications for the mother and the fetus during pregnancy, have been observed in women with SLE. In the present study, we aimed to investigate the effect of SLE development on oocyte meiosis in lupus-prone mice.
View Article and Find Full Text PDFDNA and protein-generated chimeric molecules for delivery of influenza viral epitopes in mouse and humanized NSG transfer models.
Hum Vaccin Immunother
December 2024
Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Purified subunit viral antigens are weakly immunogenic and stimulate only the antibody but not the T cell-mediated immune response. An alternative approach to inducing protective immunity with small viral peptides may be the targeting of viral epitopes to immunocompetent cells by DNA and protein-engineered vaccines. This review will focus on DNA and protein-generated chimeric molecules carrying engineered fragments specific for activating cell surface co-receptors for inducing protective antiviral immunity.
View Article and Find Full Text PDFThe Binding Landscape of Serum Antibodies: How Physical and Mathematical Concepts Can Advance Systems Immunology.
Antibodies (Basel)
June 2022
Department of Applied Analysis and Computational Mathematics, Eötvös Loránd University, 1117 Budapest, Hungary.
Antibodies constitute a major component of serum on protein mass basis. We also know that the structural diversity of these antibodies exceeds that of all other proteins in the body and they react with an immense number of molecular targets. What we still cannot quantitatively describe is how antibody abundance is related to affinity, specificity, and cross reactivity.
View Article and Find Full Text PDFAbsolute Quantitation of Serum Antibody Reactivity Using the Richards Growth Model for Antigen Microspot Titration.
Sensors (Basel)
May 2022
R&D Laboratory, Diagnosticum Zrt, 1047 Budapest, Hungary.
In spite of its pivotal role in the characterization of humoral immunity, there is no accepted method for the absolute quantitation of antigen-specific serum antibodies. We devised a novel method to quantify polyclonal antibody reactivity, which exploits protein microspot assays and employs a novel analytical approach. Microarrays with a density series of disease-specific antigens were treated with different serum dilutions and developed for IgG and IgA binding.
View Article and Find Full Text PDFWhy current quantitative serology is not quantitative and how systems immunology could provide solutions.
Biol Futur
March 2021
R&D Laboratory, Diagnosticum Zrt., Attila út 126, Budapest, 1047, Hungary.
Determination of the presence of antibodies against infectious agents, self-antigens, allogeneic antigens and environmental antigens is the goal of medical serology. Along with the standardization of these tests the community also started to use the expression "quantitative serology," referring to the fact that arbitrary units are used for the expression of results. In this review I will argue against the use of the term quantitative serology for current tests.
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