AI Article Synopsis
- Twenty patients with advanced or recurrent vulvar carcinoma were treated with either bleomycin alone or bleomycin combined with mitomycin C.
- Five out of eleven patients on bleomycin alone had an objective response, while five out of nine patients on the combination treatment also responded positively.
- No severe side effects were reported, suggesting further investigation into these treatments for patients not cured by surgery or radiation.
Article Abstract
Twenty patients with advanced and/or recurrent vulvar carcinoma were treated with bleomycin alone or combined with mitomycin C. Five of 11 patients in the bleomycin-treated group showed objective response (two complete and three partial) and five of nine patients in the bleomycin-mitomycin C-treated group showed objective response (one complete and four partial). No severe side effects were seen. Now that activity against this disease has been demonstrated for bleomycin, alone or combined with mitomycin C, attention should be directed to treating those patients not cured by surgery and radiation therapy alone.
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