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An examination of relationships between vitamin B12 status and functional measures of peripheral neuropathy in young adult vegetarians.
Front Nutr
December 2023
Nutrition Program, College of Health Solutions, Arizona State University, Phoenix, AZ, United States.
Introduction: Prevalence rates for vitamin B12 deficiency in U.S. adult vegetarians may exceed 30%, which is concerning given the role for this vitamin in numerous nervous system functions, including the synthesis of myelin sheaths.
View Article and Find Full Text PDFAutoantibody Diagnostics in Neuroimmunology: Experience From the 2018 Italian Neuroimmunology Association External Quality Assessment Program.
Front Neurol
January 2020
Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.
Neuroimmunology has impressively expanded in the past decade. Novel assays, especially cell-based assays (CBAs) can detect conformational antibodies (Abs) recognizing antigens in their native conformation. Generally, the availability of in-house and of commercial tests has improved the diagnostics, but introduced demanding laboratory tasks.
View Article and Find Full Text PDFAutoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity.
J Immunol
April 2019
Department of Neurology, Yale School of Medicine, New Haven, CT 06511;
The aim of this study was to test whether autoantibodies against neurologic surface Ags are found in nonneurologic autoimmune diseases, indicating a broader loss of tolerance. Patient and matched healthy donor (HD) sera were derived from four large cohorts: 1) rheumatoid arthritis (RA) ( = 194, HD = 64), 2) type 1 diabetes (T1D) ( = 200, HD = 200), 3) systemic lupus erythematosus (SLE) ( = 200, HD = 67; neuro-SLE = 49, HD = 33), and 4) a control cohort of neurologic autoimmunity (relapsing-remitting multiple sclerosis [MS] = 110, HD = 110; primary progressive MS = 9; secondary progressive MS = 10; neuromyelitis optica spectrum disorders = 15; and other neurologic disorders = 26). Screening of 1287 unique serum samples against four neurologic surface Ags (myelin oligodendrocyte glycoprotein, aquaporin 4, acetylcholine receptor, and muscle-specific kinase) was performed with live cell-based immunofluorescence assays using flow cytometry.
View Article and Find Full Text PDFBone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades.
J Neuroinflammation
June 2018
Gonçalo Moniz Institute, Oswaldo Cruz Foundation-FIOCRUZ, Salvador, BA, CEP 40296-710, Brazil.
Background: Diabetic neuropathy (DN) is a frequent and debilitating manifestation of diabetes mellitus, to which there are no effective therapeutic approaches. Mesenchymal stem/stromal cells (MSC) have a great potential for the treatment of this syndrome, possibly through regenerative actions on peripheral nerves. Here, we evaluated the therapeutic effects of MSC on spinal neuroinflammation, as well as on ultrastructural aspects of the peripheral nerve in DN-associated sensorial dysfunction.
View Article and Find Full Text PDFAdministration of Progesterone Throughout Pregnancy Increases Maternal Steroids Without Adverse Effect on Mature Oligodendrocyte Immunostaining in the Guinea Pig.
Reprod Sci
March 2018
1 School of Biomedical Sciences and Pharmacy, University of Newcastle, New South Wales, Australia.
Article Synopsis
- Progesterone is given to pregnant women at risk of premature labor, but studies show mixed results on its effectiveness, raising concerns about its benefits.
- In a guinea pig study, progesterone treatment increased maternal progesterone and cortisol levels, but had no impact on fetal allopregnanolone or myelination in the brain.
- The findings suggest that the lack of effect on the fetus may be due to a protective barrier in the placenta that prevents increased cortisol levels from affecting fetal development.
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