Scarce and randomly oriented oxytalan fibres are present in the connective tissue of dental pulp in both deciduous and permanent teeth.
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Expression of Elastin, F-Box and WD-40 Domain-Containing Protein 2, Fibrillin-1, and Alpha-Smooth Muscle Actin in Utilized Blood Vessels for explant culture-A New 3D in Vitro Vascular Model from Bovine Legs.
Cell Biochem Biophys
December 2024
Department of Biomaterials/Osaka Dental University, 8-1, Kuzuhahanazono-cho, Osaka, 573-1121, Japan.
Elastic fibers of the internal and external elastic laminae maintain blood vessel shapes. Impairment of smooth muscle cell function leads to vascular disease development. F-box and WD-40 domain-containing protein 2 (FBXW2) is associated with elastic fibers and osteocalcin expression for bone regeneration in the periosteum.
View Article and Find Full Text PDFNew insights into the structural role of EMILINs within the human skin microenvironment.
Sci Rep
December 2024
Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Joseph-Stelzmann-Str. 52, 50931, Cologne, Germany.
Article Synopsis
- Supramolecular ECM networks, crucial for skin structure and function, include EMILIN proteins that interact with elastin and influence cellular signaling.
- Our study mapped the distribution of EMILIN-1, -2, and -3 in human skin, revealing their role in elastic fibers and their connections with basal keratinocytes.
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Histomorphometric and molecular characterization of stromal and mineralized components in fibro-osseous lesions.
Indian J Pathol Microbiol
July 2024
Department of Oral and Maxillofacial Pathology and Microbiology, I.T.S. Center for Dental Studies and Research, Muradnagar, Ghaziabad, Uttar Pradesh, India.
Background: Indistinct and analogous histopathological features of various fibro-osseous lesions make establishing a definitive diagnosis a challenge. There is a need for additional molecular and histochemical tools to support and differentiate these lesions in order to establish a concrete diagnosis.
Materials And Methods: A retrospective analysis of biopsied lesions in formalin-fixed paraffin-embedded sections (10 cases each of fibrous dysplasia, ossifying fibroma, and cement-osseous dysplasia) retrieved from the archives was studied for immunoexpression of osteocalcin (quantitative analysis in osteocytes), collagen characterization using Azan, Picrosirus, and Toluidine blue stain for evaluating intensity and localization of collagen fibers, and morphometric analysis of vasculature (for evaluating mean vessel density as square microns).
Elastin microfibril interface-located protein 1 in fibroblasts is regulated by amphiregulin and interleukin-1α produced by keratinocytes.
Int J Cosmet Sci
October 2024
FANCL Research Institute, FANCL Corporation, Kanagawa, Japan.
Objective: The structure of elastic fibres changes with ageing. Elastin microfibril interface-located protein 1 (EMILIN-1) is known to contribute to structural changes in elastic fibres. EMILIN-1 is one of the components of elastic fibres and also colocalizes with oxytalan fibres near the epidermis.
View Article and Find Full Text PDFHistological observations of age-related changes in the epiglottis associated with decreased deglutition function in older adults.
Anat Cell Biol
September 2023
Department of Morphological Biology, Ohu University School of Dentistry, Koriyama, Japan.
Although the epiglottis plays a vital role in deglutition, histological studies of the epiglottis and surrounding ligaments associated with swallowing dysfunction are limited. Therefore, we performed histological observations to clarify age-related changes in the morphological characteristics of the epiglottis and surrounding structures. Tissue samples comprising the epiglottis and surrounding structures were collected from corpses that were both orally fed and tube-fed during their lifetimes.
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