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Osteoporosis (OP) is a prevalent metabolic bone disease globally. Currently, the development of Traditional Chinese Medicine (TCM) resources to unblock joints, strengthen bones, and enhance muscle function to regulate anti-osteogenic and anabolic metabolism and thus reshape intraosseous homeostasis was an effective way to alleviate OP. The F-E-D formula, comprising Fructus Psoraleae, Eucommia, and Drynariae Rhizoma, has shown efficacy in treating OP.
View Article and Find Full Text PDFphage ΦPNJ-9 adheres to mucus via a variant Hoc protein.
J Virol
December 2024
Key Laboratory of Animal Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Phages, as antagonists of bacteria, hold significant promise for combating drug-resistant bacterial infections. Their host specificity allows phages to target pathogenic bacteria without disrupting the gut microbiota, offering distinct advantages in the prevention and control of intestinal pathogens. The interaction between the phage and the gut plays a crucial role in the efficacy of phage-mediated bacterial killing.
View Article and Find Full Text PDFDe novo 2'-fucosyllactose biosynthesis using glucose as the sole carbon source by multiple engineered Bacillus subtilis.
Metab Eng
December 2024
Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China; Science Center for Future Foods, Jiangnan University, Wuxi, 214122, China. Electronic address:
2'-Fucosyllactose (2'-FL) is the most abundant human milk oligosaccharide and plays significant roles in gut microbiome balance, neural development, and immunoregulation. However, current fermentation schemes using multiple carbon sources increase production cost and metabolism burden. This study reported the development of an engineered Bacillus subtilis strain that produces 2'-FL using glucose as the sole carbon source.
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- The vaginal microbiota plays a significant role in the health of women and newborns, but its ecological dynamics and stability are not fully understood.
- This study investigates how nutritional resources, particularly glycogen and sialic acid, influence the composition of vaginal bacterial communities, highlighting the connection between resource availability and bacterial behavior.
- Using a new mathematical model, the research finds that bacteria associated with bacterial vaginosis (BV) thrive due to their exclusive access to certain nutrients, which helps them resist changes in their community structure, providing insights for potential BV prevention strategies.
Chemoenzymatic Labeling, Detection and Profiling of Core Fucosylation in Live Cells.
J Am Chem Soc
September 2024
Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd, Pasadena, California 91125, United States.
Article Synopsis
- Core fucosylation is an important protein modification involved in various biological processes, but existing detection methods lack specificity due to cross-reactivity with other fucosylations.
- A new chemoenzymatic strategy has been developed that uses a specific galactosyltransferase enzyme to selectively target core fucosylated glycans for detection.
- This method can detect core fucosylated glycoproteins from complex mixtures and live cells, making it useful for profiling protein-specific fucosylation levels and identifying disease biomarkers.
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