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ThermoPCD: a database of molecular dynamics trajectories of antibody-antigen complexes at physiologic and fever-range temperatures.
Database (Oxford)
March 2024
Department of Basic Medical Science, Chonnam National University, Hwasun 58128, Republic of Korea.
Progression of various cancers and autoimmune diseases is associated with changes in systemic or local tissue temperatures, which may impact current therapies. The role of fever and acute inflammation-range temperatures on the stability and activity of antibodies relevant for cancers and autoimmunity is unknown. To produce molecular dynamics (MD) trajectories of immune complexes at relevant temperatures, we used the Research Collaboratory for Structural Bioinformatics (RCSB) database to identify 50 antibody:antigen complexes of interest, in addition to single antibodies and antigens, and deployed Groningen Machine for Chemical Simulations (GROMACS) to prepare and run the structures at different temperatures for 100-500 ns, in single or multiple random seeds.
View Article and Find Full Text PDFIndividualised immunosuppression with intravenously administered donor-derived modified immune cells compared with standard of care in living donor kidney transplantation (TOL-2 Study): protocol for a multicentre, open-label, phase II, randomised controlled trial.
BMJ Open
November 2022
TolerogenixX GmbH, Heidelberg, Germany.
Article Synopsis
- The TOL-2 Study is a phase-IIb clinical trial investigating the use of modified immune cells (MIC) from living donors to provide specific immunosuppression in kidney transplantation, comparing MIC treatment with standard care.
- Sixty-three kidney transplant recipients will be randomly assigned to receive MIC treatment or serve as controls, with the trial aiming to assess the efficacy of MIC in reducing conventional immunosuppressive therapy while achieving operational tolerance-like results.
- The study will monitor patient health, looking for infections and signs of transplant rejection, alongside ethical oversight to ensure safety and efficacy throughout the process.
Synergistic activity of antibodies in the multicomponent 4CMenB vaccine.
Expert Rev Vaccines
May 2022
Research and Development Center, GSK, Siena, Italy.
Introduction: Vaccines based on multiple antigens often induce an immune response, which is higher than that triggered by each single component, with antibodies acting cooperatively and synergistically in tackling the infection.
Areas Covered: An interesting example is the antibody response induced by the 4CMenB vaccine, currently licensed for the prevention of serogroup B (MenB). It contains four antigenic components: Factor H binding protein (fHbp), Neisseria adhesin A (NadA), Neisserial Heparin Binding Antigen (NHBA), and Outer Membrane Vesicles (OMV).
China's NMPA perspective on the clinical performance of SARS-CoV-2 antigen test reagents.
Bioanalysis
March 2022
Center for Medical Device Evaluation, NMPA, Beijing, 100081, PR China.
Article Synopsis
- - The COVID-19 pandemic remains a global challenge, prompting regulatory actions for medical testing.
- - China’s medical administration released guidelines for the registration of SARS-CoV-2 antigen and antibody tests, detailing clinical evaluation requirements.
- - The article discusses evaluation methods for rapid antigen tests, including their intended use and practical applications in diagnosing COVID-19.
Aim: We investigated the frequency of overall biphasic reactions, biphasic reactions that met the diagnostic criteria of anaphylaxis, and biphasic reactions that caused a severe abnormality in vital signs in patients who visited the emergency department of a tertiary hospital.
Methods: This retrospective cohort study included patients aged 18 years or over who presented with anaphylaxis at the emergency department of a tertiary care hospital between January 2014 and December 2016. The primary outcome was the incidence of biphasic reactions that caused a severe abnormality in vital signs and developed within 7 days.
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