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Effects of two transglutaminases on innate immune responses in the oriental armyworm, Mythimna separata.
Insect Sci
July 2024
Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Article Synopsis
- Transglutaminase (TGase) plays a crucial role in the immune response of the oriental armyworm, Mythimna separata, by aiding in hemolymph coagulation and the elimination of pathogens.
- Researchers identified two TGase genes (mystgase1 and mystgase2) and found they are expressed in all larvae tissues, with their expression increased after bacterial injections.
- Manipulating these genes through techniques like RNA interference demonstrated that TGase is vital for enhancing larval phagocytic ability and resistance to bacterial infections, suggesting insights for pest control strategies.
A novel lectin with a distinct Gal_Lectin and CUB domain mediates haemocyte phagocytosis in oyster Crassostrea gigas.
Dev Comp Immunol
October 2024
College of Life Sciences, Liaoning Normal University, Dalian, 116029, Liaoning, China; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian, 116023, China; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266235, China; Dalian Key Laboratory of Aquatic Animal Disease Prevention and Control, Dalian Ocean University, Dalian, 116023, China.
Invertebrate lectins exhibit structural diversity and play crucial roles in the innate immune responses by recognizing and eliminating pathogens. In the present study, a novel lectin containing a Gal_Lectin, a CUB and a transmembrane domain was identified from the Pacific oyster Crassostrea gigas (defined as CgGal-CUB). CgGal-CUB mRNA was detectable in all the examined tissues with the highest expression in adductor muscle (11.
View Article and Find Full Text PDFA C-type lectin with dual carbohydrate recognition domains functions in innate immune response in Asian corn borer, Ostrinia furnacalis.
Insect Sci
May 2024
Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.
C-type lectins (CTLs) act as pattern recognition receptors (PRRs) to initiate the innate immune response in insects. A CTL with dual carbohydrate recognition domains (CRDs) (named immulectin-4 [IML-4]) was selected from the Ostrinia furnacalis transcriptome dataset for functional studies. We cloned the full-length complementary DNA of O.
View Article and Find Full Text PDFA DM9-containing protein from crab Eriocheir sinensis functions as a novel multipotent pattern recognition receptor.
Fish Shellfish Immunol
February 2024
College of Life Sciences, Liaoning Normal University, Dalian, 116029, Liaoning, China; Southern Laboratory of Ocean Science and Engineering, Guangdong, Zhuhai, 519000, China; Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, 116023, China; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266235, China; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian, 116023, China. Electronic address:
DM9-containing protein in invertebrates functions as pattern recognition receptor (PRR) to play significant roles in innate immunity. In the present study, a novel DM9-containg protein (defined as EsDM9CP-1) was identified from the Chinese mitten crab Eriocheir sinensis. EsDM9CP-1 is composed of 330 amino acids containing a Methyltransf_FA domain and two tandem DM9 repeats.
View Article and Find Full Text PDFA novel DM9-containing protein 7 involved in regulating the expression of CgMyD88 and CgIL-17 in oyster Crassostrea gigas.
Dev Comp Immunol
January 2024
College of Life Sciences, Liaoning Normal University, Dalian, 116029, Liaoning, China; Southern Laboratory of Ocean Science and Engineering, Guangdong, Zhuhai, 519000, China; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266235, China; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian, 116023, China; Dalian Key Laboratory of Aquatic Animal Disease Prevention and Control, Dalian Ocean University, Dalian, 116023, China. Electronic address:
The DM9-containing proteins have been identified as pattern recognition receptors (PRRs) to recognize invading pathogens and subsequently mediate downstream signal pathways, playing essential roles in innate immune responses of molluscs. In the present study, a novel DM9-containing protein (named as CgDM9CP-7) was identified from Pacific oyster Crassostrea gigas, which contained two tandem DM9 repeats similar to the previously identified CgDM9CPs. The mRNA transcripts of CgDM9CP-7 were found to be constitutively expressed in all the tested tissues including haemolymph, gill, hepatopancreas, mantle, adductor muscle and labial palp.
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