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Can a combination of nanofat and freeze-dried human amniotic membrane enhance full-thickness wound healing? An animal study using rabbit models.
Narra J
December 2024
Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Previous studies have explored nanofat stimulating tissue regeneration and maturation, promoting remodeling through its rich content of growth factors and stem cells; however, comprehensive data on its use in full-thickness wounds remains limited. The aim of this study was to evaluate the effectiveness of combining nanofat with freeze-dried human amniotic membrane (FDHAM) for treating full-thickness wounds in a rabbit model. An animal experimental study using a post-test control group design was conducted.
View Article and Find Full Text PDFAssessing Second Trimester Ferning in Diagnosing Preterm Prelabor Rupture of Membranes.
Am J Perinatol
January 2025
MFM, Albany Medical Center, Albany, United States.
Preterm prelabor rupture of membranes (PPROM) diagnosis is made through visualization of amniotic fluid (pooling), nitrizine testing, sonographic low amniotic fluid, and microscopic detection of amniotic fluid arborization (ferning). Data exits on the specificity and sensitivity of ferning detection but has not focused on the second trimester. Our objective is to evaluate the presence of ferning in transvaginally collected amniotic fluid in pregnancies with known second trimester PPROM to determine if there is a difference in ferning based on gestational age and sample drying time.
View Article and Find Full Text PDFEfficacy of Split-Thickness Thin Amniotic Membrane Graft for Closure of Refractory or Large Macular Holes.
Retina
January 2025
Kresge Eye Institute/Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Purpose: To assess the effectiveness of split-thickness amniotic membrane (SAM) grafts in achieving closure of refractory or large macular holes (MH).
Methods: This retrospective study reviewed data from patients who underwent surgical repair of MHs using SAM grafts between January 2019 and December 2023. Key parameters, including best-corrected visual acuity (BCVA) and MH size, were evaluated both preoperatively and postoperatively.
Too Much of a Good Thing: Updated Current Management and Perinatal Outcomes of Polyhydramnios.
J Med Ultrasound
November 2024
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
Amniotic fluid assessment is crucial in prenatal ultrasound to monitor fetal conditions, with polyhydramnios, characterized by excessive amniotic fluid, affecting 1%-2% of pregnancies. Polyhydramnios is linked to complications such as placental abruption, preterm labor, congenital anomalies, and postpartum hemorrhage, emphasizing the need for early detection and management. While idiopathic causes account for 60%-70% of cases, other causes include impaired fetal swallowing and increased urine production due to maternal, fetal, and placental conditions.
View Article and Find Full Text PDFStudy on the repair function of radiation-induced salivary gland injury using human amniotic mesenchymal stem cells pre treated with hypoxia.
J Stomatol Oral Maxillofac Surg
January 2025
Department of Stomatology, the Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai 519090, China. Electronic address:
Objective: To investigate the reparative effect of hypoxia pretreated hAMSCs on radiation-induced damage to salivary gland function in mice.
Methods: hAMSCs were separated from human amniotic tissues by mechanical and enzymatic digestion methods and a 15 Gy electron beam was used to locally irradiate the neck of mouse to create a salivary gland injury model. The mouse models were randomly divided into four groups: control group, IR+PBS group, IR+Nor group and IR+HP group.
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