Immunotherapy of colon cancer: prospects for developing immunogenic vaccines based on autologous serological typing.

Exploration of specific immunization as a means of cancer therapy has been hampered by the lack of knowledge of human cancer antigens. Recent progress in the serological definition of cell surface antigens of malignant melanomas, renal cancers, and astrocytomas provides a new basis for the construction of immunogenic vaccines and their clinical testing. Application of the same approach to colon cancer depends on the development of methods which permit continuous growth of colon cancer cells in tissue culture.