[Anti-glafenine circulating antibodies: demonstration and frequency in acute renal insufficiency following intake of glafenine in toxic doses].

From 1970 to 1981, acute glafenineeeeeeee poisoning was observed in 106 patients, including 37 with acute renal insufficiency (ARI). From 1977 to 1982, the search for anti-glafenin antibodies was carried out systematically by direct and indirect tests for antiglobulin on erythrocytes, and by leucoagglutination and complement fixation tests on platelets in the presence of glafenin. An antibody was detected in only one of the 17 ARI patients studied. This antibody, IgM, has been studied along with glafenin, floctafenin, antrafenin and their metabolites. The rareness of such an antibody confirms the direct nephrotoxic action of glafenin, a drug responsible for half of the renal insufficiencies observed in an intensive care unit specialized in toxicology.