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Modified Hospital Frailty Risk Score (mHFRS) as a Tool to Identify and Predict Outcomes for Hospitalised Older Adults at Risk of Frailty.
J Frailty Sarcopenia Falls
December 2024
Department of Geriatric Medicine, Changi General Hospital, Singapore.
Article Synopsis
- The study investigates the effectiveness of the modified Hospital Frailty Risk Score (mHFRS) in identifying frail hospitalized older adults, comparing it with the original Hospital Frailty Risk Score (HFRS) and the Clinical Frailty Scale (CFS).
- A review of 3,042 patients over 65 years old was conducted, revealing that the CFS identified 46.3% as frail, with frail patients generally being older, more likely female, and having longer hospital stays and higher mortality rates.
- The mHFRS showed a significant correlation with both CFS and HFRS, proving to be effective in classifying patients, especially identifying non-frail individuals, and suggesting it as a
A comparison of frailty measures in population-based data for patients with colorectal cancer.
Age Ageing
May 2024
Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.
Background: Numerous studies have revealed age-related inequalities in colorectal cancer care. Increasing levels of frailty in an ageing population may be contributing to this, but quantifying frailty in population-based studies is challenging.
Objective: To assess the feasibility, validity and reliability of the Hospital Frailty Risk Score (HFRS), the Secondary Care Administrative Records Frailty (SCARF) index and the frailty syndromes (FS) measures in a national colorectal cancer cohort.
Epidemiological and clinical characteristics of death from hemorrhagic fever with renal syndrome: a meta-analysis.
Front Microbiol
April 2024
College of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Article Synopsis
- Hemorrhagic fever with renal syndrome (HFRS) is a serious infectious disease with five distinct stages and a mortality rate between 1-15%, characterized by increased vascular permeability and renal injury.
- A comprehensive study analyzed data from 37 articles involving over 140,000 HFRS patients to identify clinical features associated with fatalities, revealing that deceased patients were generally older and had higher incidences of smoking, hypertension, and diabetes.
- Patients who did not survive exhibited significant differences in various health complications and laboratory results, such as elevated leukocyte counts and altered liver function tests, indicating more severe organ dysfunction and the need for intensive care like continuous renal therapy.
Rosuvastatin as a Supplemental Treatment for the Clinical Symptoms of Nephropathia Epidemica: A Pilot Clinical Study.
Viruses
February 2024
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia.
Nephropathis epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS), is an acute zoonotic disease endemic in the Republic of Tatarstan. This study aimed to assess the impact of rosuvastatin on the clinical and laboratory results of NE. A total of 61 NE patients and 30 controls were included in this study; 22 NE patients and 7 controls received a daily dose of rosuvastatin (10 mg) for ten consecutive days.
View Article and Find Full Text PDFSurvival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels.
Cancers (Basel)
February 2024
Centre for Pharmacoepidemiology and Drug Safety, Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester M13 9PT, UK.
Primary endocrine therapy (PET) offers non-surgical treatment for older women with early-stage breast cancer who are unsuitable for surgery due to frailty or comorbidity. This research assessed all-cause and breast cancer-specific mortality of PET vs. surgery in older women (≥70 years) with oestrogen-receptor-positive early-stage breast cancer by frailty and comorbidity levels.
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