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MiRNA-223-5p inhibits hypoxia-induced apoptosis of BMSCs and promotes repair in Legg-Calvé-Perthes disease by targeting CHAC2 and activating the Wnt/β-catenin signaling pathway.
PLoS One
January 2025
School of Clinical Medicine, Guizhou Medical University, Guiyang, China.
Legg-Calvé-Perthes disease (LCPD) involves femoral head osteonecrosis caused by disrupted blood supply, leading to joint deformity and early osteoarthritis. This study investigates the role of miRNA-223-5p in regulating hypoxia-induced apoptosis and enhancing osteogenesis in bone marrow mesenchymal stem cells (BMSCs). Utilizing a juvenile New Zealand white rabbit model of LCPD established through femoral neck ligation, we transfected BMSCs with miR-223-5p mimics, inhibitors, and controls, followed by hypoxic exposure.
View Article and Find Full Text PDFIncidence and complication rate of arthroplasty in Perthes disease management: A systematic review and meta-analysis.
J Taibah Univ Med Sci
February 2025
Department of Research Center, Almoosa Specialist Hospital, Almoosa College of Health Sciences, Al-Ahsa, KSA.
Background: Perthes disease presents a challenge in orthopedic management, often necessitating surgical intervention such as arthroplasty. This meta-analysis systematically evaluated the rate of occurrence and complications associated with arthroplasty in Perthes disease.
Methods: A comprehensive search was conducted across PubMed, Web of Sciences, Scopus, and Cochrane Library databases to identify relevant studies.
Longitudinal Improvement of Quality of Life in Children With Legg-Calve-Perthes Disease Treated With Proximal Femoral Varus Osteotomy.
J Pediatr Orthop
January 2025
Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center.
Background: Proximal femoral varus osteotomy (PFVO) is commonly performed to improve femoral head containment and decrease deformity in Legg-Calve-Perthes disease (LCPD). Little is known about how PFVO impacts the quality of life after surgery. The purpose of this study was to determine the longitudinal changes to patient-reported physical, mental, and social health measures after PFVO.
View Article and Find Full Text PDFNetwork Analysis of Legg-Calve-Perthes Disease and Its Comorbidities.
J Clin Med
January 2025
Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Republic of Korea.
: Legg-Calvé-Perthes disease (LCPD) is characterized by idiopathic avascular necrosis of the femoral head in children. There are several hypotheses regarding the cause of LCPD; however, the exact cause remains unclear. Studies on comorbidities can provide better insight into the disease.
View Article and Find Full Text PDFDiagnosis and Management of Legg-Calvé-Perthes Disease in the Obese Pediatric Population.
J Orthop Physician Assist
January 2024
Department of Biomedical Sciences, West Liberty University, West Liberty, WV, United States of America.
Legg-Calvé-Perthes Disease (LCPD) is a condition marked by temporary blood flow disruption to the proximal femur, commonly afflicting children aged 15 and younger. The etiology of the disease is often idiopathic and involves the development of avascular necrosis of the femoral head, subsequently leading to bone weakening and deformity. Obesity exacerbates LCPD, correlating with delayed diagnosis, increased disease severity, and bilateral involvement.
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