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How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health.
Clin Epigenetics
January 2025
Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, 17003, Girona, Spain.
Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and small non-coding RNA (sncRNA) expression and regulation. Smoking may induce DNA hypermethylation in genes related to anti-oxidation and insulin resistance. Paternal diet and obesity are associated with greater risks of metabolic dysfunction in offspring via epigenetic alterations in the sperm.
View Article and Find Full Text PDFAn Infant With Variant: A Novel Etiology of 46,XY DSD and Literature Review.
JCEM Case Rep
January 2025
Department of Pediatrics, Division of Pediatric Endocrinology, Yale School of Medicine, New Haven, CT 06510, USA.
46,XY sex reversal 11 (SRXY11) is a rare and recently identified form of 46,XY difference in sexual development (DSD), caused by variants in the DEAH-Box Helicase 37 gene (). is crucial for ribosome biogenesis, but its specific role in gonadal development remains unclear. The genital phenotype varies widely, ranging from typical female to typical male.
View Article and Find Full Text PDFLichtenstein repair for giant inguinoscrotal hernia: a retrospective case-control study.
Hernia
December 2024
Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital MedicalUniversity, Beijing, 100043, China.
Purpose: Giant inguinoscrotal hernia (GISH) is a rare condition in high-income regions, and the management presents a significant challenge for surgeons. A retrospective analysis was conducted of a single center's experience in treating GISH by Lichtenstein approach. The objective was to gain insight into the characteristics of GISH and assess the clinical efficacy of the Lichtenstein approach, as well as the degree of improvement in patient quality of life (QoL).
View Article and Find Full Text PDFScrotal hematoma and subsequent abscess following urethral catheterisation.
BMJ Case Rep
November 2024
Department of Community Medicine, Kameyama, Mie Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Tsu, Mie, Japan.
A man in his early 70s with advanced Lewy body dementia was admitted to the hospital for treatment of aspiration pneumonia and a severe sacral pressure ulcer. An indwelling urinary catheter was placedto manage urinary retention and to prevent urine contamination of the sacral ulcer.On the 25th day of hospitalisation, swelling and tenderness developed in the patient's left scrotum.
View Article and Find Full Text PDFHide and Seek: Elmer Belt, Agnes, and the Battle over Castration in Transsexual Surgery, 1953-1962.
Bull Hist Med
November 2024
In the 1950s, the idea of sex change increasingly assumed the mainstay of public interest. As psychiatrists and psychologists developed new understandings of gender, the role of surgeons is often overlooked in the early history of sex reassignment. This article explores the work of one such doctor, Elmer Belt, a urologist based in Los Angeles.
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