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Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging.
Sci Rep
July 2024
R&D Pierre Fabre Dermo-Cosmétique & Personal Care, Toulouse, France.
Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging. Senescent cells have a specific secretome, called the senescence-associated secretory phenotype (SASP) that includes MMPs, CXCLs and S100A8/9. Reducing the SASP with senotherapeutics is a promising strategy to reduce skin aging.
View Article and Find Full Text PDFmining to glean SNPs of pharmaco-clinical importance: an investigation with reference to the Indian populated SNPs.
In Silico Pharmacol
July 2023
Computational Omics Lab, Centre of Bioinformatics, University of Allahabad, Prayagraj, 211002 India.
Unlabelled: Drugs pharmacology is defined by pharmacokinetics and pharmacodynamics and both of them are affected by genetic variability. Genetic variability varies from population to population, and sometimes even within the population, it exists. Single nucleotide polymorphisms (SNPs) are one of the major genetic variability factors which are found to be associated with the pharmacokinetics and pharmacodynamics process of a drug and are responsible for variable drug response and clinical phenotypes.
View Article and Find Full Text PDFSafety of Hydrocortisone Premedication Discontinuation in Patients with Inflammatory Bowel Disease on Maintenance Therapy with Infliximab: a Prospective Clinical and Pharmacological Study.
J Crohns Colitis
May 2021
Service de Gastroentérologie, Université de Paris, APHP, Hôpital Saint-Louis, Paris, France.
Background: Hydrocortisone premedication reduces the risk of antibodies to infliximab [ATIs] formation in patients receiving infliximab [IFX] therapy for inflammatory bowel disease [IBD].
Aim: We aimed to determine the safety of hydrocortisone premedication withdrawal in IBD patients with sustained clinical response on maintenance therapy with IFX.
Methods: We performed an observational prospective pharmacoclinical study in a tertiary referral centre, including all consecutive IBD outpatients with no previous IFX infusion reaction and in clinical remission on maintenance IFX [alone or in combination therapy] for at least 6 months.
Pharmacoclinical audit on the use of digitalis in patients aged over 75 years hospitalized in an acute geriatric unit.
Geriatr Psychol Neuropsychiatr Vieil
June 2018
Département de médecine interne-gériatrie-thérapeutique, CHU Rouen Saint-Julien, Le Petit Quevilly, France.
Unlabelled: Digitalis remains a treatment that is difficult to manage, especially in the elderly.
Methods: A retrospective, unicentric study carried out within the unit of Internal medicine and geriatrics, Reims University Hospital Center, between January and June 2014. Collection of all patients hospitalized, after 75 years, receiving treatment with digitalis, either as soon as they enter (present on the usual prescription of the patient), during their hospitalization and on their exit.
Report: Palladium glutathione, N-acetylcysteine, D-penicillamine conjugation chemistry.
Pak J Pharm Sci
January 2018
Institute of Pharmaceutical Sciences, People's University of Medical and Health Sciences, Nawabshah, Pakistan.
The metalloelement Palladium has a number of potential Pharmaco-clinical advantages. Palladium compounds have antiviral, antibacterial, neuroprotective and antitumor properties. However studies have also indicated some mild to serious toxic effects of Palladium metalloelements.
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