Histologic malignancy grading and prognosis from a biopsy only was retrospectively investigated in 92 cases of stages I and II of cancer of the vulva treated with electrocoagulation. A scoring was made of several histologic variables. The score proved to be a better predictor of survival than any other single factor analysed, including clinical staging. Depth of invasion did not significantly influence survival, thus indicating improper use of "microinvasion", if defined only by depth of invasion.
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http://dx.doi.org/10.1016/0020-7292(83)90048-6 | DOI Listing |
Cureus
December 2024
Department of Pathology, Government Medical College Satna, Satna, IND.
Background Oral squamous cell carcinoma is a common problem among tobacco chewers and related products in developing countries like India. Histopathological examination evaluates and confirms the diagnosis of oral SCC. Clinical examination and molecular profiling by histopathological examination (HPE) are important prognostic tools used in clinical practice.
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January 2025
Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Introduction: Magnetic resonance imaging (MRI) is essential for brain imaging, but conventional methods rely on qualitative contrast, are time-intensive, and prone to variability. Magnetic resonance finger printing (MRF) addresses these limitations by enabling fast, simultaneous mapping of multiple tissue properties like T1, T2. Using dynamic acquisition parameters and a precomputed signal dictionary, MRF provides robust, qualitative maps, improving diagnostic precision and expanding clinical and research applications in brain imaging.
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January 2025
Department of Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Tumor Treating Fields (TTFields) has emerged as a significant adjunctive component in the treatment of high-grade gliomas following the EF-14 trial in 2017. The incorporation of TTFields, alongside cyclic temozolomide therapy, has demonstrated improved patient outcomes when the usage exceeds 18 h per day (75% usage). analysis of the EF-14 trial has demonstrated that therapy usage exceeding 90% is associated with an additional benefit, while rates above 50% have also proven effective in literature.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
School of Medicine, The South China University of Technology, Guangzhou, Guangdong, China.
Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor lesion of pancreatic ductal adenocarcinoma (PDAC), which has poor prognosis with a short median overall survival of 6-12 months and a low 5-year survival rate of approximately 3%. It is crucial to remove PanIN lesions to prevent the development of invasive PDAC, as PDAC spreads rapidly outside the pancreas. This review aims to provide the latest knowledge on PanIN risk, pathology, cellular origin, genetic susceptibility, and diagnosis, while identifying research gaps that require further investigation in this understudied area of precancerous lesions.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: In recent years, the incidence of patients with colorectal neuroendocrine neoplasms (CRNENs) has been continuously increasing. When diagnosed, most patients have distant metastases. Liver metastasis (LM) is the most common type of distant metastasis, and the prognosis is poor once it occurs.
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