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Development of a Stringent Ex Vivo-Burned Porcine Skin Wound Model to Screen Topical Antimicrobial Agents.
Antibiotics (Basel)
December 2024
Combat Wound Care Group, CRT 4, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX 78234, USA.
: Due to rising antibiotic-resistant microorganisms, there is a pressing need to screen approved drugs for repurposing and to develop new antibiotics for controlling infections. Current in vitro and ex vivo models have mostly been unsuccessful in establishing in vivo relevance. In this study, we developed a stringent ex vivo-burned porcine skin model with high in vivo relevance to screen topical antimicrobials.
View Article and Find Full Text PDFResponse to the letter to the editor regarding "The efficacy of an alcohol-based nasal antiseptic versus mupirocin or an iodophor for preventing SSIs using a meta-analysis".
Am J Infect Control
January 2025
Department of Internal of Medicine, Virginia Commonwealth University Health, Richmond, VA.
In vitro antibacterial and antibiofilm effects of mupirocin spray against Staphylococcus pseudintermedius.
Pol J Vet Sci
December 2024
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, 80 Daehak-ro, Daegu, 41566, Korea.
Mupirocin is an effective antibiotic for infectious skin diseases. However, mupirocin is formulated as an ointment and is difficult to apply in canine systemic pyoderma. Therefore, many clinicians reformulate mupirocin off-label ointment into a spray.
View Article and Find Full Text PDFEnhancing transdermal delivery of chrysomycin A for the treatment of cutaneous melanoma and MRSA infections using Skin-Penetrating Peptide-Functionalized deformable liposomes.
Int J Pharm
December 2024
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals & College of Pharmaceutical Science, Zhejiang University of Technology, 310014 Hangzhou, China; Zhejiang Key Laboratory of Green, Low-carbon and Efficient Development of Marine Fishery Resources, Hangzhou 310014, China. Electronic address:
Article Synopsis
- Transdermal drug delivery using SPACE-modified liposomal chrysomycin A (CA@SPACE-LP) shows promise for treating skin diseases like melanoma and MRSA infections.
- In vitro studies reveal that CA@SPACE-LP significantly enhances drug penetration into skin layers, achieving a threefold increase in intradermal drug concentration compared to free chrysomycin A.
- In vivo results indicate that CA@SPACE-LP effectively suppresses melanoma tumor growth by about 60% and outperforms conventional treatments for MRSA, suggesting its potential for combined cancer and infection therapy.
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