1. The wasp Megascolia flavifrons stings larvae of the stag beetle Oryctes nasicornis on the ventral side of all segments, except the last three, which do not contain nerve ganglia. 2. Experiments indicate a central rather than a peripheral action of the venom. 3. From pharmacological analysis it is concluded that the venom does not contain cholinergic or serotonergic activity, but contains histamine- and bradykinin-like substances. 4. The presence of histamine was confirmed by a radioenzymatic method.
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From an extract of the venom reservoirs of the wasp Megascolia flavifrons two kinins have been isolated. The sequences of amino acids are: Arg-Pro-Pro-Gly-Phe-Thr-Pro-Phe-Arg (Thr6-bradykinin) and Arg-Pro-Pro-Gly-Phe-Thr-Pro-Phe-Arg-Lys-Ala (Thr6-bradykinin-Lys-Ala). The bradykinin-like effects of the venom on a number of vertebrate smooth muscle preparations can be explained by the actions of these kinins.
View Article and Find Full Text PDFBlock of synaptic transmission in insect CNS by toxins from the venom of the wasp Megascolia flavifrons (Fab.).
Comp Biochem Physiol C Comp Pharmacol Toxicol
November 1987
Department of Pharmacology, University of Amsterdam, The Netherlands.
1. The effects of the venom and its fractions of Megascolia flavifrons have been studied on synaptic transmission and axonal excitability of the giant interneuron of the cockroach. 2.
View Article and Find Full Text PDFMegascoliakinin, a bradykinin-like compound in the venom of Megascolia flavifrons Fab. (Hymenoptera: Scoliidae).
Comp Biochem Physiol C Comp Pharmacol Toxicol
November 1984
The pharmacological and immunological properties of the venom of Megascolia flavifrons are compared with those of bradykinin and a number of bradykinin analogues. It is postulated that this venom contains a peptide, megascoliakinin, with a bradykinin-like sequence of amino acids, elongated at the C-terminal end with an unknown structure.
View Article and Find Full Text PDFSmooth muscle contracting compounds in the venom of Megascolia flavifrons (Hym: Scoliidae) with notes on the stinging behaviour.
Comp Biochem Physiol C Comp Pharmacol Toxicol
September 1983
1. The wasp Megascolia flavifrons stings larvae of the stag beetle Oryctes nasicornis on the ventral side of all segments, except the last three, which do not contain nerve ganglia. 2.
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