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Alternative Role of B/b Knob-Hole Interactions in the Fibrin Assembly.
Biochemistry
January 2025
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9, Leontovycha 9, Kyiv 01054, Ukraine.
The self-assembly of fibrin is a vital process in blood clotting, primarily facilitated by the interactions between knobs "A" and "B" in the central E region of one molecule and the corresponding holes "a" and "b" in the peripheral D regions of two other fibrin molecules. However, the precise function of the interactions between knob "B" and hole "b" during fibrin polymerization remains a subject of ongoing debate. The present study focuses on investigating intermolecular interactions between knob "B" and hole "b".
View Article and Find Full Text PDFKnockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition.
Sci Rep
January 2025
Department of Biological Sciences, University of North Texas, 1511 West Sycamore Street, Denton, TX, 76203, USA.
Transmembrane proteins (TMEMs) are embedded in cell membranes and often have poorly understood functions. Our RNAseq analysis identified 89 tmem genes in zebrafish thrombocytes, leading to further investigation through knockdown experiments and gill bleeding assays. Knockdown of tmem242 significantly increased bleeding, indicating a role in hemostasis.
View Article and Find Full Text PDFDedicator of Cytokinesis 2 regulates cytoskeletal actin dynamics and is essential for platelet biogenesis and functions.
Cardiovasc Res
January 2025
Department of Pharmacology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Aims: Dedicator of Cytokinesis 2 (DOCK2), a member of the DOCK family of Guanine nucleotide exchange factors that specifically act on the Rho GTPases including Rac and Cdc42, plays pivotal roles in the regulation of leukocyte homeostasis. However, its functions in platelets remain unknown.
Methods And Results: Using mice with genetic deficiency of DOCK2 (Dock2-/-), we showed that Dock2-/-mice exhibited a macrothrombocytopenic phenotype characterized as decreased platelet count and enlarged platelet size by transmission electron microscopy.
Photomodulated Transient Catalytic Constitutional Dynamic Networks and Reaction Circuits.
Angew Chem Int Ed Engl
January 2025
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
A method to photomodulate dynamically transient DNA-based reaction circuits and networks is introduced. The method relies on the integration of photoresponsive o-nitrobenzyl-phosphate ester-caged DNA hairpin with a "mute" reaction module. Photodeprotection (λ=365 nm) of the hairpin structure separates a fuel strand triggering the dynamic, transient, operation of the DNA circuit/network.
View Article and Find Full Text PDFFirst- vs. Second-Generation Autologous Platelet Concentrates and Their Implications for Wound Healing: Differences in Proteome and Secretome.
Bioengineering (Basel)
November 2024
Department of Oral and Maxillofacial Surgery, University Medical Center, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
Article Synopsis
- This study compares the effectiveness of second-generation autologous platelet concentrate, Platelet-Rich Fibrin (PRF), with first-generation Platelet-Rich Plasma (PRP) in promoting wound healing through various biological assessments.
- It was found that PRF contains a higher concentration of leukocytes and has a more favorable effect on macrophage polarization, which is crucial for reducing inflammation and promoting healing.
- Additionally, PRF demonstrated superior pro-angiogenic potential, evidenced by increased neo-vessel formation and branching in vivo, making it a better option for regenerative medicine applications than PRP.
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