AI Article Synopsis
- Researchers used immune sera to identify the distribution of three somatostatin-related peptides (SS14, SS28, SS28(1-12)) in the hippocampus.
- There are at least two distinct neuronal systems for these peptides, including local branching cells in the polymorphic layers and a concentrated terminal field in the dentate gyrus's molecular layer, potentially linked to the entorhinal-dentate projection.
- SS28 is mainly found in cell bodies, while SS28(1-12) is more localized in neuronal processes and terminals; SS14 was not detected during this study.
Article Abstract
By using immune sera which recognize one or more of the 3 peptides, somatostatin-14 (SS14), somatostatin-28 (SS28) and somatostatin-28(1-12) (SS28(1-12)) we have characterized their immunohistochemical distribution in the hippocampal formation. There exist at least two independent neuronal systems containing pro-somatostatin-related peptides: an intrinsic system of cells in the polymorphic layers which branch locally, and a dense terminal field in the molecular layer of the dentate gyrus that may constitute a portion of the entorhinal-dentate projection. In addition, SS28 is the dominant form present in cell bodies, whereas SS28(1-12) is preferentially localized in neuronal processes and terminals. We could not detect SS14 immunohistochemically.
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| http://dx.doi.org/10.1016/0304-3940(82)90165-3 | DOI Listing |
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