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An update on the pharmacotherapy of gout.
Expert Opin Pharmacother
January 2025
Department of Rheumatology, Royal Free London NHS Foundation Trust, London, UK.
Introduction: Gout is a common form of acute inflammatory arthritis caused by the deposition of monosodium urate crystals within synovium of joints. This leads to severe pain, reducing quality of life for patients with this condition.
Areas Covered: This review summarizes the treatment of both acute flares of gout and urate-lowering therapy based on guidance from various major international societies.
Knocking Out of UDP-Glycosyltransferase Gene via CRISPR/Cas9 in Reveals Its Function in Detoxification of Insecticides.
J Agric Food Chem
September 2024
Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Sciences, China Agricultural University, Beijing 100193, China.
The role of insect UDP-glycosyltransferases (UGTs) in the detoxification of insecticides has rarely been reported. A UGT gene was previously found overexpressed in a fenvalerate-resistant strain of . Herein, was cloned, and its involvement in insecticide detoxification was investigated.
View Article and Find Full Text PDFNonalcoholic fatty liver disease (NAFLD) is considered a risk factor for severe COVID-19, but the mechanism remains unknown. This study used bioinformatics to help define the relationship between these diseases. The GSE147507 (COVID-19), GSE126848 (NAFLD), and GSE63067 (NAFLD-2) datasets were screened using the Gene Expression Omnibus.
View Article and Find Full Text PDFEfficacy and safety of urate-lowering agents in asymptomatic hyperuricemia: systematic review and network meta-analysis of randomized controlled trials.
BMC Nephrol
June 2022
Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Background: Asymptomatic hyperuricemia was found to be associated with increased cardiovascular disease risk but the potential benefits of urate-lowering therapy (ULT) remain controversial. We conducted a systematic review and network meta-analysis (NMA) with frequentist model to estimate the efficacy and safety of ULT in asymptomatic hyperuricemia.
Methods: MEDLINE, Embase, and Scopus were searched without language restrictions.
The induction and inhibition of UDP-glycosyltransferases in Haemonchus contortus and their role in the metabolism of albendazole.
Int J Parasitol Drugs Drug Resist
August 2022
Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského, 1203, Hradec Králové, Czech Republic. Electronic address:
Albendazole (ABZ) is an anthelmintic frequently used to treat haemonchosis, a common parasitosis of ruminants caused by the gastrointestinal nematode Haemonchus contortus. This parasite is able to protect itself against ABZ via the formation of inactive ABZ-glycosides. The present study was designed to deepen the knowledge about the role of UDP-glycosyltransferases (UGTs) in ABZ glycosylation in H.
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