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The effects of autophagy-modifying drugs chloroquine and lithium on the skin melanoma microenvironment.
Tissue Cell
January 2025
Laboratory of Ultrastructural Research, Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 6 Arbuzov St., Novosibirsk 630117, Russia.
Background: Skin melanoma is a highly metastatic cancer with an increasing global incidence. Despite advancements in immunotherapy, new treatment strategies based on tumor biology are essential for improving outcomes and developing novel therapies. Autophagy plays a critical role in melanoma cell metabolism and affects the tumor microenvironment (TME).
View Article and Find Full Text PDFFacial Foramen Diagnostic and Surgical Role as Reference Points in Asymmetries-Cone-Beam Computed Tomography Preliminary Study.
J Clin Med
January 2025
Department of Pediatric Dentistry and Preclinical Dentistry, Medical University in Wroclaw, Krakowska 26, 50-425 Wrocław, Poland.
Facial asymmetry can be attributed to a multitude of underlying causes. Multiple reference points can be utilized for guidance in surgery planning. The scope of mandibular overgrowth and asymmetry should always be measured on CBCT radiographs (cone-beam computed tomography).
View Article and Find Full Text PDFExploring the Potential Effectiveness of Oil and Its Nano-Emulsion on (Lepidoptera: Nolidae).
Insects
January 2025
Plant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.
(Lepidoptera: Nolidae) is a major pest of cotton and other crops in Egypt, and the widespread use of insecticides has led to resistance. This study evaluates, for the first time, the bioactivity of (Malpighiales: Euphorbiaceae) oil and its nano-emulsion (CTNE) against 25 newly hatched larvae of Boisd. We assessed their biological effects across different developmental stages and performed histological and ultrastructural examinations.
View Article and Find Full Text PDFNew Insight on the Sublethal Effect of Bt-Cry1Ab in (Fabricius): Tissular Distribution of Cry1Ab, Ultrastructural Alterations and the Lysosomal Response.
Insects
December 2024
Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center, Southwest University, Chongqing 400715, China.
Bt has been applied as a gene source for insect-resistant transgenic crops, which represents efficient control of insect pests. In this study, we evaluated the pesticidal specificity of one Bt maize strain, DBN9936, that expresses Cry1Ab protein in larvae. The results showed that this Bt maize is active against the younger larvae while causing a sublethal effect on older larvae.
View Article and Find Full Text PDFRecent Advances in the Clinical Translation of Small-Cell Lung Cancer Therapeutics.
Cancers (Basel)
January 2025
Eli Lilly and Company, Indianapolis, IN 46221, USA.
Small-cell lung cancer (SCLC) is a recalcitrant form of cancer, representing 15% of lung cancer cases globally. SCLC is classified within the range of neuroendocrine pulmonary neoplasms, exhibiting shared morphologic, ultrastructural, immunohistochemical, and molecular genomic features. It is marked by rapid proliferation, a propensity for early metastasis, and an overall poor prognosis.
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