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Engineering silica nanocoated whole-cell asymmetric biocatalyst for efficient preparation of a key chiral intermediate of (S)-Rivastigmine.
J Biotechnol
January 2025
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China. Electronic address:
In our previous study, the whole cells containing an aldo-keto reductase (yhdN) and glucose dehydrogenase (GDH) were constructed and applied in a stereoselective carbonyl reduction reaction to prepare (S)-NEMCA-HEPE, being a key chiral intermediate of (S)-Rivastigmine which is widely prescribed for the treatment of Alzheimer's disease. Although the conversion and enantiomeric excess (e.e.
View Article and Find Full Text PDFLong-term exposure to PM and its constituents and visual impairment in schoolchildren: A population-based survey in Guangdong province, China.
Environ Int
January 2025
Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080 China. Electronic address:
Background: Exposure to fine particulate matter (PM) has been linked to visual impairment. Nevertheless, evidence associating PM constituents with visual impairment in schoolchildren is sparse.
Objectives: To explore the effects of long-term exposure to PM and its constituents on visual impairment.
An "on-off" electrochemical immunosensor for the detection of the glycan antigen CA125 by amplification signals using electropositive COFs.
Talanta
January 2025
College of Chemistry and Materials, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, 330022, China.
Cancer Antigen 125 (CA125), is a high molecular weight mucinous glycoprotein found on the surface of ovarian cancer cells. Generally, 90 % of women may appear a high concentration of CA125 when they got the cancer; thus, CA125 can act as a marker for ovarian cancer diagnosis and therapeutic evaluation. COFs have been widely used for disease detection due to their structural stability, high loading capacity and biocompatibility.
View Article and Find Full Text PDFMultifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation.
ACS Nano
January 2025
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China.
Atherosclerosis (AS) is a prevalent inflammatory vascular disease characterized by plaque formation, primarily composed of foam cells laden with lipids. Despite lipid-lowering therapies, effective plaque clearance remains challenging due to the overexpression of the CD47 molecule on apoptotic foam cells, inhibiting macrophage-mediated cellular efferocytosis and plaque resolution. Moreover, AS lesions are often associated with severe inflammation and oxidative stress, exacerbating disease progression.
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