To assess the role in breast-cancer aetiology of oestrogenic substances apparently produced by intestinal bacteria from faecal residues associated with a high-fat diet and other absorbable and possibly carcinogenic colonic substances, cancer incidence and mortality were studied in 2425 women in the UK who had previously had total colectomy and terminal ileostomy, mostly for ulcerative colitis for Crohn's disease. The incidence of breast cancer in this group of women was no lower than would be expected, although there was a slight deficiency of deaths from this cause. These findings suggest that, at least in adult life, the colon is not involved in the aetiology of breast cancer. There were pronounced excesses of rectal and bile-duct cancers in ulcerative colitis patients despite previous colectomy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0140-6736(83)92644-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gastrointestinal complications of hepatic glycogen storage disease: a national survey questionnaire study in China.
Orphanet J Rare Dis
January 2025
Department of Pediatrics, Guangdong Provincial People's Hospital, The Second School of Clinical Medicine, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Background: Hepatic glycogen storage diseases (GSD) are inborn errors of metabolism with abnormal storage or utilization of glycogen, a complex disease with significant genetic heterogeneity and similar clinical manifestations. This study aimed to describe the gastrointestinal symptoms and endoscopic features of hepatic GSD, including types Ia, Ib, III, VI, and IX, to provide evidence for etiology and treatment.
Methods: A national cohort survey questionnaire was distributed to patients diagnosed with GSD type Ia, Ib, III, VI, and IX through genetic testing or their parents in mainland China in May 2022.
Help-seeking for depression among Vietnamese migrant workers in Japan and factors related to their intentions to seek help from a psychiatrist: a cross-sectional study.
BMC Public Health
January 2025
Center for Basic Medical Research, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara-City, Tochigi, 324-8501, Japan.
Background: Foreign workers are at risk for depression, and Vietnamese people tend to be reluctant to seek professional mental health care. Although Vietnamese people are the largest population among foreign workers in Japan, evidence concerning their help-seeking experiences and strategies to promote help-seeking in this population is lacking. This study aimed to identify the percentage of Vietnamese migrant workers in Japan who have sought help from healthcare professionals for depressive symptoms and to explore the factors related to their intentions to seek help from a psychiatrist.
View Article and Find Full Text PDFFactors influencing role preferences in decision-making of healthy women with BRCA1/2 pathogenic variants: subanalysis from a randomised controlled decision coaching trial.
BMC Cancer
January 2025
Faculty of Medicine, University of Cologne and Institute for Health Economics and Clinical Epidemiology, University Hospital Cologne, Cologne, Germany.
Background: Patients who actively engage in their medical decision-making processes can experience better health outcomes. This exploratory study aimed to identify predictors of preferred and actual roles in decision-making in healthy women with BRCA1/2 pathogenic variants (PVs).
Methods: Women with BRCA1/2 PVs without a history of breast and/or ovarian cancer were recruited in six centres across Germany.
Decision-making behavior of blood glucose management and its influencing factors in pregnant women with gestational diabetes mellitus.
BMC Pregnancy Childbirth
January 2025
Department of Obstetrics, the Affiliated Hospital of Qingdao University, Qingdao, China.
Background: Currently, most studies only focus on the glucose management level and self- management behavior of pregnant women with gestational diabetes mellitus, but lack analysis and discussion on their decision-making behavior and influencing factors during glucose management.
Aim: This study aimed to investigate the decision-making behavior of blood glucose management and its influencing factors among pregnant women with gestational diabetes mellitus in China.
Methods: This was a prospective study.
Prevalence of non-vaccine high-risk HPV cervical infections in vaccinated women: a systematic review and meta-analysis.
BMC Infect Dis
January 2025
Programa de Pós-graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Background: Human Papillomavirus (HPV) is the most common sexually transmitted lower genital tract infection worldwide and the main etiological factor of cervical cancer (CC). Since 2006, vaccines have been implemented to reduce CC-related morbidity and mortality. This systematic review and meta-analysis aimed to evaluate the prevalence of cervical infections by non-vaccine high-risk HPV (HR-HPV) types in women vaccinated against types 16 and 18.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!