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Onset of pancreatic cancer before and after acute pancreatitis: A multicenter longitudinal cohort study.
Pancreatology
December 2024
Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation, University of Szeged, Szeged, Hungary. Electronic address:
Background: Pancreatic cancer (PC) is a leading cause of cancer mortality, often diagnosed at advanced stages. Acute pancreatitis (AP), particularly idiopathic cases, may serve as an early indicator of PC.
Objective: This multicenter cohort study investigated the incidence of PC before and after an AP episode, focusing on idiopathic AP and the role of pseudocysts as potential early markers for PC development.
Topically Applied N,N-Dimethylglycine Sodium Salt Enhances Human Skin Blood Flow by Inducing Endothelial Nitric Oxide Release.
J Invest Dermatol
December 2024
Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:
Discharge protocol in acute pancreatitis: an international survey and cohort analysis.
Sci Rep
December 2023
Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Article Synopsis
- There is a lack of discharge protocols for acute pancreatitis (AP) patients, which the Hungarian Pancreatic Study Group (HPSG) aims to address with a new, validated protocol based on laboratory data and symptoms.
- An international survey revealed that 87.5% of participating medical centers do not have discharge protocols, but those that do see shorter hospital stays and lower readmission rates.
- The HPSG discharge protocol resulted in the lowest average length of hospital stay and demonstrated safety through a low readmission rate, highlighting the need for developing and validating more standardized discharge protocols for AP care.
N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release.
Int J Mol Sci
July 2023
Department of Immunology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
N,N-dimethylglycine (DMG) is a naturally occurring compound being widely used as an oral supplement to improve growth and physical performance. Thus far, its effects on human skin have not been described in the literature. For the first time, we show that N,N-dimethylglycine sodium salt (DMG-Na) promoted the proliferation of cultured human epidermal HaCaT keratinocytes.
View Article and Find Full Text PDFDetailed Characteristics of Post-discharge Mortality in Acute Pancreatitis.
Gastroenterology
September 2023
Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Translational Pancreatology Research Group, Interdisciplinary Center of Excellence for Research Development and Innovation, University of Szeged, Szeged, Hungary. Electronic address:
Article Synopsis
- Patients discharged after acute pancreatitis (AP) face a significantly higher mortality risk than the general population, with a first-year mortality rate almost double that of in-hospital mortality.
- Key risk factors for post-discharge mortality include age, existing medical conditions, severity of illness, and certain lab results upon admission.
- Major causes of death in the first 90 days post-discharge are cardiac failure and AP-related infections, while later deaths are often linked to cancer-related issues and other infections, highlighting the need for comprehensive follow-up care.
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