AI Article Synopsis
- The study monitored the immune response of children after they received a live influenza vaccine, using various cellular and humoral tests to assess their immune status.
- A direct correlation was found between the levels of neutralizing antibodies and the lymphocyte stimulation indices measured by the blast transformation assay (BTA).
- Vaccinated children exhibited reduced lymphocyte reactivity and a decrease in T lymphocyte counts, indicating that the influenza vaccine has weak sensitizing properties.
Article Abstract
Development of immunological status of children after oral administration of a live influenza vaccine was followed using different tests of the cellular (blast transformation assay, identification of T, B and nil lymphocytes) and humoral (haemagglutination inhibition test, neuraminidase-inhibition test, neutralization test) immune response. Direct correlation was observed between the increase of neutralizing antibody and the lymphocyte stimulation indices in blast transformation assay (BTA). In vaccinated children the reactivity of lymphocytes was reduced and the amount of T lymphocytes decreased. The influenza vaccine has been shown to possess weak sensitizing properties.
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