[Indices of autoimmunity in schizophrenic patients with an unfavorable course after long-term treatment with neuroleptics].

The authors examined 176 patients with schizophrenia running an unfavourable course, treated with neuroleptics for a long time; 20 oligophrenics on prolonged neuroleptic therapy and 47 healthy subjects. The immunological status of the patients was characterized by high neutrophil damage in the presence of a complex of brain antigens, in particular those of the subcortical area (trunk and optic tuber), marked formation of hemolytic plaques, inhibition of spontaneous rosette-formation, low antithymic activity of the serum, and by a slightly elevated level of blood histamine. Administration of chlorpromazine in different concentrations led to a stimulation of plaque formation and inhibition of rosette-formation. The groups of patients with high and low responsiveness were distinguished.