AI Article Synopsis
- Sulfinalol hydrochloride, an antihypertensive drug, was studied in dogs after being given intravenously, using a two-compartment model to analyze how the drug behaves in the body.
- The results showed a mean alpha-phase constant of 33.3 hr-1 and a beta-phase constant of 0.52 hr-1, with plasma clearance at 2.30 L/kg X hr, and distribution volume around four times the dog's body weight.
- Only 7.5% of the dose was found in urine, indicating renal clearance rates similar to the dog's normal glomerular filtration rate, and the drug's hypotensive effects correlated more with tissue levels than plasma levels.
Article Abstract
The pharmacokinetic behavior of sulfinalol hydrochloride, an antihypertensive agent with vasodilator and beta-adrenergic blocking activity, was determined in dogs after intravenous administration. The plasma concentrations of sulfinalol HCl were fit to an open two-compartment body model. The mean values for the alpha- and beta-phase constants were 33.3 hr-1 and 0.52 hr-1, respectively. The mean plasma clearance was 2.30 L/kg X hr. The steady-state volume of distribution was approximately four times the body weight of the animals. The urine data gave renal clearance rates approximately equal to the normal glomerular filtration rate in the dog. About 7.5% of the administered dose was excreted in the urine as free sulfinalol hydrochloride. The time course of the hypotensive effect of sulfinalol appears to be better correlated with calculated tissue levels of drug than with observed plasma levels.
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