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AIP56, an AB toxin secreted by subsp. , has tropism for myeloid cells.
Front Immunol
January 2025
Fish Immunology and Vaccinology Group, Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Porto, Portugal.
Introduction: The AB-type toxin AIP56 is a key virulence factor of Photobacterium damselae subsp. piscicida (Phdp), inducing apoptosis in fish immune cells. The discovery of AIP56-like and AIP56-related toxins in diverse organisms, including human-associated Vibrio strains, highlights the evolutionary conservation of this toxin family, suggesting that AIP56 and its homologs may share conserved receptors across species.
View Article and Find Full Text PDFProteomic Analysis Is Needed to Understand the Vulnerability of Sea Anemones to Climate Change.
J Proteome Res
January 2025
Department of Hydrobiology, Division of Biological and Health Sciences, Ecotoxicology Laboratory, Universidad Autónoma Metropolitana, Iztapalapa Unit, Mexico City C. P. 09340, Mexico.
Sea anemones play a crucial role in marine ecosystems. Recent studies have highlighted their physiological and ecological responses to thermal stress. Therefore, our objective was to perform a proteomic analysis of sea anemones in the Gulf of Mexico, subjected to thermal stress, to understand whether these organisms activate specific processes to resist increased temperature.
View Article and Find Full Text PDFCharacterisation of Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes .
Toxins (Basel)
January 2025
Leibniz Institute of Photonic Technology (Leibniz-IPHT), Leibniz Center for Photonics in Infection Research (LPI), Germany and InfectoGnostics Research Campus, 07745 Jena, Germany.
Leukocidins of (.) are bicomponent toxins that form polymeric pores in host leukocyte membranes, leading to cell death and/or triggering apoptosis. Some of these toxin genes are located on prophages and are associated with specific hosts.
View Article and Find Full Text PDFBioactive Steroids with Structural Diversity from the South China Sea Soft Coral sp. and Sponge sp.
Mar Drugs
January 2025
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China.
A chemical investigation of the soft coral sp. and the sponge sp. from the South China Sea led to the isolation of five steroids, including two new compounds ( and ) and one known natural product ().
View Article and Find Full Text PDFFive New Indole Alkaloid Derivatives from Deep-Sea Fungus AF1.
Mar Drugs
December 2024
School of Pharmaceutical Sciences, GBRCE for Functional Molecular Engineering, Sun Yat-sen University, Guangzhou 510006, China.
One new gliotoxin derivative fumianthrogliotoxin (), one new indoquizoline alkaloid 3-(methyl propionate) indoquizoline (), and three novel indole alkaloids, anthroxyindole (), (±)-asperfumiindole A (), and (±)-asperfumiindole B (), together with 16 known compounds (-), were isolated from the culture of deep-sea derived fungus AF1. Their chemical structures and absolute configurations were determined through the analysis of NMR data in combination with electronic circular dichroism (ECD) calculations and other spectroscopic analyses. Compounds - and - were evaluated for anti-pulmonary fibrosis activity.
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