The effect of L-aspartate on the 32Pi incorporation of phospholipids, was studied on slices of rat cerebral cortex. This amino acid produced an inhibitory effect in concentrations 0.01-10 mM, which was more evident at 120 min. This effect was not stereospecific and did not imply a change in Pi uptake and in nucleotides approximately P precursors. The inhibition was present in PS, PC, PE and to a lesser extent in PI. On liver slices 1 mM L-aspartate had the opposite effect, stimulating the incorporation of 32Pi into total phospholipids. Our results suggest that the effect of L-aspartate is by a non-specific mechanism, probably not mediated by a receptor.
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