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Glycobiology of psoriasis: A review.
J Autoimmun
January 2025
Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University, No.38, Xueyuan Road, Haidian, Beijing, 100191, China. Electronic address:
Psoriasis is a chronic inflammatory skin disease with etiologies related to genetics, immunity, and the environment. It is characterized by excessive proliferation of keratinocytes and infiltration of inflammatory immune cells. Glycosylation is a post-translational modification of proteins that plays important roles in cell adhesion, signal transduction, and immune cell activation.
View Article and Find Full Text PDFCase report on anti-GQ1b antibody syndrome: initial symptoms of pupil palsy and periorbital pain.
Front Immunol
January 2025
Department of Neurology, Chengdu Second People's Hospital, Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
Anti-GQ1b antibody syndrome is a spectrum of autoimmune disorders affecting nervous systems. We report a case of a 53-year-old woman presenting mydriasis with acute onset of periorbital pain, photophobia, and subsequently, diplopia. Despite weakly positive anti-GQ1b IgG antibody, the patient exhibited atypical features with isolated ophthalmoplegia and absence of classic Miller-Fisher syndrome triad.
View Article and Find Full Text PDFGanglioside GM1 Alleviates Propofol-Induced Pyroptosis in the Hippocampus of Developing Rats via the PI3K/AKT/NF-κB Signaling Cascade.
Int J Mol Sci
November 2024
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
In pediatric and intensive care units, propofol is widely used for general anesthesia and sedation procedures as a short-acting anesthetic. Multiple studies have revealed that propofol causes hippocampal injury and cognitive dysfunction in developing animals. As is known, GM1, a type of ganglioside, plays a crucial role in promoting nervous system development.
View Article and Find Full Text PDFClinical and biochemical abnormalities in a feline model of GM2 activator deficiency.
Mol Genet Metab
January 2025
Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, AL 36849, United States of America; Department of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849, United States of America. Electronic address:
Though it has no catalytic activity toward GM2 ganglioside, the GM2 activator protein (GM2A) is essential for ganglioside hydrolysis by facilitating the action of lysosomal ß-N-acetylhexosaminidase. GM2A deficiency results in death in early childhood due to rapid central nervous system deterioration similar to the related GM2 gangliosidoses, Tay-Sachs disease and Sandhoff disease. This manuscript further characterizes a feline model of GM2A deficiency with a focus on clinical and biochemical parameters that may be useful as benchmarks for translational therapeutic research.
View Article and Find Full Text PDFBiochemical investigation and in silico analysis of the therapeutic efficacy of Ipriflavone through Tet-1 Surface-Modified-PLGA nanoparticles in Streptozotocin-Induced Alzheimer's like Disease: Reduced oxidative damage and etiological Descriptors.
Int J Pharm
January 2025
Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21511, Egypt. Electronic address:
Article Synopsis
- Ipriflavone (IPRI) is used to prevent postmenopausal bone loss and offers antioxidant and cognitive benefits, but it has low bioavailability due to poor solubility.
- In this study, IPRI was formulated into targeted poly-lactic-co-glycolic acid (PLGA) nanoparticles with Tet-1 peptide to enhance its therapeutic effects in a rat model of Alzheimer's disease (AD), exacerbated by streptozotocin (STZ) injections.
- Results showed that IPRI nanoparticles were more effective than free IPRI in reducing cognitive dysfunction, oxidative stress, and neurodegenerative changes, leading to improved neuronal cell viability and reduced Alzheimer's
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