By means of both immunohistology and immunodiffusion a number of 7 by definition from NANB hepatitis suffering patients were found to belong to an unique antigen-antibody system. These patients responded to NANB infection with certain similarities: 1. The course of the disease exhibited a phasic pattern since increases in SGPT activity were observed at days 47 +/-- 10, 76 +/- 14, 117 +/- 18 and 157 +/- 7. 2. Increases of Gamma-GT were found to exceed values as observed in HAV and HBV infection. Thus, Gamma-GT increases are incriminated as further characteristic of NANB hepatitis.
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