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Effect of myogenic tone on agonist-mediated vasoconstriction in isolated arteries: A computational study.
Comput Methods Programs Biomed
January 2025
Department of Biotechnology and School of Electrical Sciences, Odisha University of Technology and Research, Techno Campus, Ghatikia, Bhubaneswar, 751029 Odisha, India. Electronic address:
Background And Objective: Vasoconstriction of the resistance artery is mainly determined by an integrated action of multiple local stimuli acting on the vascular smooth muscle cells, which include neuronal delivery of α-adrenoceptor agonists and intraluminal pressure. The contractile activity of the arterial wall has been extensively studied ex vivo using isolated arterial preparations and myography techniques. However, agonist-mediated vasoconstriction response is often confounded by local effects of other stimuli (e.
View Article and Find Full Text PDFPharmacological characterization of alpha adrenoceptor-mediated motor responses in the rat colon.
Neurogastroenterol Motil
January 2025
Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Barcelona, Spain.
Background: Inhibitory neuromuscular transmission in the gastrointestinal tract is mediated by intrinsic nitrergic and purinergic neurons. Purines activate G protein-coupled receptor P2Y receptors, increasing intracellular Ca that activates small conductance calcium-activated potassium (SK) channels. Little is known about the effect of adrenergic receptor activation on intestinal smooth muscle.
View Article and Find Full Text PDFDevelopmental Changes in the Excitation-Contraction Mechanisms of the Ventricular Myocardium and Their Sympathetic Regulation in Small Experimental Animals.
J Cardiovasc Dev Dis
August 2024
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi 274-8510, Japan.
The developmental changes in the excitation-contraction mechanisms of the ventricular myocardium of small animals (guinea pig, rat, mouse) and their sympathetic regulation will be summarized. The action potential duration monotonically decreases during pre- and postnatal development in the rat and mouse, while in the guinea pig it decreases during the fetal stage but turns into an increase just before birth. Such changes can be attributed to changes in the repolarizing potassium currents.
View Article and Find Full Text PDFNew morpholine-containing pyrimidinones act on α-adrenoceptors.
Eur J Pharmacol
September 2024
Centro Acadêmico de Vitória, Universidade Federal de Pernambuco - UFPE, Vitória de Santo Antão-PE, Brazil. Electronic address:
Drugs that act on α-adrenoceptors may contain morpholine and pyrimidinone heterocycles. The aim of this study was to synthesize a series of pyrimidinones (S6a-e and S8) and characterize their α-adrenoceptor activity. Cytotoxicity assays (MTT and LDH) were performed in A7r5 and HUVECs.
View Article and Find Full Text PDFPheochromocytoma During Pregnancy: A Hidden Cause for Hypertension.
Cureus
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Obstetrics and Gynecology, Unidade Local de Saúde (ULS) de Braga, Braga, PRT.
Pheochromocytoma, a rare but potentially serious condition, poses challenges in timely identification, especially during pregnancy due to misconceptions about pregnancy-related hypertension causes. However, paroxysmal symptoms heighten diagnostic suspicion. The diagnosis relies on biochemical confirmation of catecholamine hypersecretion followed by imaging for tumor localization.
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