Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.2042-7158.1982.tb04724.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mononuclear cell membranes: stabilization by reproterol and cromoglycate, destabilization by fenoterol and salbutamol.
Arzneimittelforschung
April 2006
Gustav Embden Center of Biological Chemistry, University of Frankfurt/Main, Germany.
Electron paramagnetic resonance (EPR) spectroscopy with spin labels 5- and 16-doxyl-stearic acid (DSA) was used to differentiate between actions of beta-agonists on human mononuclear cell membrane. Reproterol (CAS 13055-82-8), salbutamol (CAS 51022-70-9) and fenoterol (CAS 1944-12-3) compared to cromoglycate (CAS 15826-37-6) were used at concentrations of 10-100 nmol/l per 10(7) cells. With reproterol, order and polarity was not much changed, whereas salbutamol and fenoterol significantly destabilized the membrane to similar extent.
View Article and Find Full Text PDFEffect of reproterol either alone or combined with disodium cromoglycate on airway responsiveness to methacholine.
Pulm Pharmacol Ther
September 2005
Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, D-22927 Grosshansdorf, Germany.
Regular use of inhaled beta2-agonists might lead to tolerance as reflected in a loss of bronchoprotection. In vitro-data suggest that this might be prevented by disodium cromoglycate (DSCG). Therefore, we studied the effect of the beta2-agonist reproterol in combination with DSCG.
View Article and Find Full Text PDFDifferent mechanisms of action of beta2-adrenergic receptor agonists: a comparison of reproterol, fenoterol and salbutamol on monocyte cyclic-AMP and leukotriene B4 production in vitro.
Eur J Med Res
July 2004
Department of Pneumology, Allergology and Sleep Medicine, Medical Outpatient Clinic, Bonn University Hospital, Germany.
Background: Beta2-adrenergic receptor agonists have several effects on airway function, most of which are mediated in a variety of cell types resulting in increased c-AMP-production and inhibition of inflammatory mediator production. However, their stimulating effects on cAMP-production became known to be inversed by increasing phosphodiesterase (PDE) activity and degradation of cAMP. Therefore, in this study we have evaluated the efficacy of reproterol, a dual acting beta2-adrenoceptor agonist and PDE-inhibitor, as compared to salbutamol and fenoterol with respect to production of cAMP and LTB4 in cultured monocytes.
View Article and Find Full Text PDFInhibition by reproterol of cAMP PDE in intact mastocytoma P-815 cells.
Pulm Pharmacol Ther
November 2004
INSERM U400, School of Medicine, 8 rue du Général Sarrail, 94010, Créteil Cédex, France.
In vitro studies in rat mastocytes and human monocytes suggested that reproterol (a selective beta(2)-adrenoceptor agonist with a theophylline moiety) exerts anti-inflammatory actions through inhibition of cyclic AMP (cAMP) PDE activity. Thus, reproterol was tested for its ability to inhibit cAMP PDE in cultured mouse mastocytoma P-815 cells. cAMP PDE activity was measured in intact cells by spectrofluorometry using the fluorescent substrate 2'-O-anthraniloyl cAMP.
View Article and Find Full Text PDFReproterol--A monomolecular combination of orciprenaline and theophylline: novel aspects of its mode of action in asthma.
Respiration
September 1999
Department of Pulmonary Diseases, Medical Policlinic, University Hospital, Bonn, Germany.
Background And Objective: Reproterol is a monomolecular combination of orciprenaline and theophylline used as beta-adrenergic agonist to induce bronchodilation in bronchial asthma. Since the mechanism of action of reproterol has not been investigated so far, its potential anti-inflammatory activity in asthma remains still unknown. Therefore, we have studied in vitro whether the theophylline component of the reproterol molecule might enhance the stimulatory effect of the beta-adrenoceptor on cAMP production resulting in suppression of inflammatory mediator production.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!