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The two extremes of Hansen's disease-Different manifestations of leprosy and their biological consequences in an Avar Age (late 7th century CE) osteoarchaeological series of the Duna-Tisza Interfluve (Kiskundorozsma-Daruhalom-dűlő II, Hungary).
PLoS One
June 2022
Department of Biological Anthropology, University of Szeged, Szeged, Hungary.
To give an insight into the different manifestations of leprosy and their biological consequences in the Avar Age of the Hungarian Duna-Tisza Interfluve, two cases from the 7th-century-CE osteoarchaeological series of Kiskundorozsma-Daruhalom-dűlő II (Hungary; n = 94) were investigated. Based on the macromorphology of the bony changes indicative of Hansen's disease, KD271 (a middle-aged male) and KD520 (a middle-aged female) represent the two extremes of leprosy. KD271 appears to have an advanced-stage, long-standing near-lepromatous or lepromatous form of the disease, affecting not only the rhinomaxillary region but also both upper and lower limbs.
View Article and Find Full Text PDFLeprosy affects facial nerves at the main trunk: neurolysis can possibly avoid transfer procedures.
Plast Reconstr Surg
October 1998
Department of Plastic and Reconstructive Surgery, Surgical University Clinic of Vienna, Ludwig Boltzmann Institute for Experimental Plastic Surgery, Austria.
The predilective sites of lesions in leprous peripheral nerves are well established, and their surgical decompression is common practice when sensorimotor disorders persist after medication. By contrast, the precise localization of leprous facial neuropathy still remains unclear, and musculofascial transfers have been the only type of surgical treatment. The goal of this study was to clarify where leprosy affects facial nerves and to determine whether neurolysis might suffice to restore facial function.
View Article and Find Full Text PDFSevere pan-sensory neuropathy in leprosy.
Int J Lepr Other Mycobact Dis
March 1994
Acworth Leprosy Hospital Society for Research, Rehabilitation and Education in Leprosy, Bombay, India.
The sensory loss which occurs in leprosy is essentially cutaneous, resulting from centripetally ascending infection, the host cellular response and fibrosis, from dermal to certain mixed nerves. The hallmark is pain/temperature and touch/pressure loss. Muscle denervation is a byproduct of mixed nerve involvement.
View Article and Find Full Text PDFThe use of transcutaneous electric nerve stimulation is new to dermatologists but has a long history. A list of published applications includes use in therapy for postherpetic neuralgia, increased peripheral circulation, itching, varicose ulcers, ischemic ulcers, diabetic neuropathy, leprous neuritis, would healing, increased survival of skin flaps, Raynaud's phenomenon, scleroderma, esophageal dysmotility, and glossodynia.
View Article and Find Full Text PDFHeel ulcer in leprosy treated with fasciocutaneous island flap from the instep of the sole.
Scand J Plast Reconstr Surg Hand Surg
December 1991
All Africa Leprosy Rehabilitation and Training Centre (ALERT), Addis Ababa, Ethiopia.
Twenty-four leprous patients with longstanding ulcer of the weight bearing area of the heel underwent reconstruction by use of fasciocutaneous island flap from the instep. One flap was lost because the vascular pedicle was accidentally severed during the dissection. Infection delayed healing in three cases, and one patient developed minor necrosis of the edge of the flap without any adverse consequences.
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